Efaroxan HCl
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MedKoo CAT#: 540114

CAS#: 89197-00-2

Description: Efaroxan HCl is an inhibitor of α2-adrenergic receptors, imidazoline-1 receptors, and ATP-sensitive K channels. It improves glucose tolerance, alters opiod-mediated tolerance and antinociception signaling pathways, and decreases symptoms of Parkinson's Disease.


Chemical Structure

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Efaroxan HCl
CAS# 89197-00-2

Theoretical Analysis

MedKoo Cat#: 540114
Name: Efaroxan HCl
CAS#: 89197-00-2
Chemical Formula: C13H17ClN2O
Exact Mass: 252.1029
Molecular Weight: 252.74
Elemental Analysis: C, 61.78; H, 6.78; Cl, 14.03; N, 11.08; O, 6.33

Price and Availability

Size Price Availability Quantity
10.0mg USD 210.0 2 weeks
25.0mg USD 350.0 2 weeks
50.0mg USD 530.0 2 weeks
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Synonym: Efaroxan HCl; RX 821037A; RX821037A; RX-821037A; EU-0100521; EU0100521; EU 0100521;

IUPAC/Chemical Name: 2-(2-ethyl-2,3-dihydrobenzofuran-2-yl)-4,5-dihydro-1H-imidazole hydrochloride

InChi Key: DWOIUCRHVWIHAH-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H16N2O.ClH/c1-2-13(12-14-7-8-15-12)9-10-5-3-4-6-11(10)16-13;/h3-6H,2,7-9H2,1H3,(H,14,15);1H

SMILES Code: CCC1(C2=NCCN2)OC3=C(C=CC=C3)C1.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 252.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Berridge TL, Doxey JC, Roach AG, Smith CF. Selectivity profile of the alpha
2-adrenoceptor antagonist efaroxan in relation to plasma glucose and insulin
levels in the rat. Eur J Pharmacol. 1992 Mar 24;213(2):205-12. PubMed PMID:
1355733.