WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 540114
Description: Efaroxan HCl is an inhibitor of α2-adrenergic receptors, imidazoline-1 receptors, and ATP-sensitive K channels. It improves glucose tolerance, alters opiod-mediated tolerance and antinociception signaling pathways, and decreases symptoms of Parkinson's Disease.
MedKoo Cat#: 540114
Name: Efaroxan HCl
Chemical Formula: C13H17ClN2O
Exact Mass: 252.1029
Molecular Weight: 252.74
Elemental Analysis: C, 61.78; H, 6.78; Cl, 14.03; N, 11.08; O, 6.33
Synonym: Efaroxan HCl; RX 821037A; RX821037A; RX-821037A; EU-0100521; EU0100521; EU 0100521;
IUPAC/Chemical Name: 2-(2-ethyl-2,3-dihydrobenzofuran-2-yl)-4,5-dihydro-1H-imidazole hydrochloride
InChi Key: DWOIUCRHVWIHAH-UHFFFAOYSA-N
InChi Code: InChI=1S/C13H16N2O.ClH/c1-2-13(12-14-7-8-15-12)9-10-5-3-4-6-11(10)16-13;/h3-6H,2,7-9H2,1H3,(H,14,15);1H
SMILES Code: CCC1(C2=NCCN2)OC3=C(C=CC=C3)C1.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 252.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Berridge TL, Doxey JC, Roach AG, Smith CF. Selectivity profile of the alpha
2-adrenoceptor antagonist efaroxan in relation to plasma glucose and insulin
levels in the rat. Eur J Pharmacol. 1992 Mar 24;213(2):205-12. PubMed PMID: