WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 526380
Description: B022 is a novel inhibitor of NF-kappaB-inducing kinase (NIK), protecting liver from toxin-induced inflammation, oxidative stress, and injury.
MedKoo Cat#: 526380
Chemical Formula: C19H16ClN5OS
Exact Mass: 397.0764
Molecular Weight: 397.881
Elemental Analysis: C, 57.36; H, 4.05; Cl, 8.91; N, 17.60; O, 4.02; S, 8.06
This product is not in stock, which may be available by custom synthesis.
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Synonym: B022; B-022; B 022;
IUPAC/Chemical Name: 4-[1-(2-Amino-5-chloro-pyrimidin-4-yl)-2,3-dihydro-1H-indol-6-yl]-2-thiazol-2-yl-but-3-yn-2-ol
InChi Key: OKFYOOFXVBCIIP-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H16ClN5OS/c1-19(26,17-22-7-9-27-17)6-4-12-2-3-13-5-8-25(15(13)10-12)16-14(20)11-23-18(21)24-16/h2-3,7,9-11,26H,5,8H2,1H3,(H2,21,23,24)
SMILES Code: CC(O)(C1=NC=CS1)C#CC2=CC3=C(C=C2)CCN3C4=NC(N)=NC=C4Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 397.881 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Ren X, Li X, Jia L, Chen D, Hou H, Rui L, Zhao Y, Chen Z. A small-molecule inhibitor of NF-κB-inducing kinase (NIK) protects liver from toxin-induced inflammation, oxidative stress, and injury. FASEB J. 2017 Feb;31(2):711-718. doi: 10.1096/fj.201600840R. Epub 2016 Nov 8. PubMed PMID: 27871061.