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MedKoo CAT#: 526380

CAS#: 1202764-53-1

Description: B022 is a novel inhibitor of NF-kappaB-inducing kinase (NIK), protecting liver from toxin-induced inflammation, oxidative stress, and injury.

Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-06-02. Prices are subject to change without notice.

B022 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 526380
Name: B022
CAS#: 1202764-53-1
Chemical Formula: C19H16ClN5OS
Exact Mass: 397.0764
Molecular Weight: 397.881
Elemental Analysis: C, 57.36; H, 4.05; Cl, 8.91; N, 17.60; O, 4.02; S, 8.06

Synonym: B022; B-022; B 022;

IUPAC/Chemical Name: 4-[1-(2-Amino-5-chloro-pyrimidin-4-yl)-2,3-dihydro-1H-indol-6-yl]-2-thiazol-2-yl-but-3-yn-2-ol


InChi Code: InChI=1S/C19H16ClN5OS/c1-19(26,17-22-7-9-27-17)6-4-12-2-3-13-5-8-25(15(13)10-12)16-14(20)11-23-18(21)24-16/h2-3,7,9-11,26H,5,8H2,1H3,(H2,21,23,24)


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Ren X, Li X, Jia L, Chen D, Hou H, Rui L, Zhao Y, Chen Z. A small-molecule inhibitor of NF-κB-inducing kinase (NIK) protects liver from toxin-induced inflammation, oxidative stress, and injury. FASEB J. 2017 Feb;31(2):711-718. doi: 10.1096/fj.201600840R. Epub 2016 Nov 8. PubMed PMID: 27871061.