VU6004256

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MedKoo CAT#: 526000

CAS#: 2011034-33-4

Description: VU6004256 is a novel selective muscarinic receptor M1 positive allosteric modulator (PAM).


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-26. Prices are subject to change without notice.

VU6004256 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526000
Name: VU6004256
CAS#: 2011034-33-4
Chemical Formula: C25H25F2N5O2
Exact Mass: 465.1976
Molecular Weight: 465.5048
Elemental Analysis: C, 64.51; H, 5.41; F, 8.16; N, 15.04; O, 6.87


Synonym: VU6004256, VU-6004256, VU 6004256

IUPAC/Chemical Name: 4,6-Difluoro-1-[6-(1-methyl-1H-pyrazol-4-yl)-pyridin-3-ylmethyl]-1H-indole-3-carboxylic acid (2(R)-hydroxy-cyclohex-1(R)-yl)-amide

InChi Key: ZZMZFDCJQBUOOI-GMAHTHKFSA-N

InChi Code: InChI=1S/C25H25F2N5O2/c1-31-13-16(11-29-31)20-7-6-15(10-28-20)12-32-14-18(24-19(27)8-17(26)9-22(24)32)25(34)30-21-4-2-3-5-23(21)33/h6-11,13-14,21,23,33H,2-5,12H2,1H3,(H,30,34)/t21-,23-/m0/s1

SMILES Code: O[C@@H]1[C@@H](NC(C2=CN(CC3=CC=C(C4=CN(C)N=C4)N=C3)C5=CC(F)=CC(F)=C52)=O)CCCC1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Grannan MD, Mielnik CA, Moran SP, Gould RW, Ball J, Lu Z, Bubser M, Ramsey AJ, Abe M, Cho HP, Nance KD, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW, Jones CK. Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M(1) PAM VU6004256. ACS Chem Neurosci. 2016 Dec 21;7(12):1706-1716. doi: 10.1021/acschemneuro.6b00230. Epub 2016 Oct 5. PubMed PMID: 27617634; PubMed Central PMCID: PMC5231396.