YM-022
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532982

CAS#: 145084-28-2

Description: YM-022 is a highly potent and selective non-peptide CCK-BR silent antagonist (Ki values are 68 pM and 63 nM at CCK-BR and CCK-AR, respectively).

Chemical Structure

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YM-022
CAS# 145084-28-2
Instruction

Theoretical Analysis

MedKoo Cat#: 532982
Name: YM-022
CAS#: 145084-28-2
Chemical Formula: C32H28N4O3
Exact Mass: 516.22
Molecular Weight: 516.600
Elemental Analysis: C, 74.40; H, 5.46; N, 10.85; O, 9.29

Price and Availability

Size Price Availability Quantity
5mg USD 230
10mg USD 425
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Synonym: YM-022; YM 022; YM022.

IUPAC/Chemical Name: 3-(3-methylphenyl)-1-[(3R)-1-[2-(2-methylphenyl)-2-oxoethyl]-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]urea

InChi Key: YCXFHPUBGMMWJQ-PMERELPUSA-N

InChi Code: InChI=1S/C32H28N4O3/c1-21-11-10-15-24(19-21)33-32(39)35-30-31(38)36(20-28(37)25-16-7-6-12-22(25)2)27-18-9-8-17-26(27)29(34-30)23-13-4-3-5-14-23/h3-19,30H,20H2,1-2H3,(H2,33,35,39)/t30-/m0/s1

SMILES Code: O=C(NC1=CC=CC(C)=C1)N[C@H]2C(N(CC(C3=CC=CC=C3C)=O)C4=CC=CC=C4C(C5=CC=CC=C5)=N2)=O

Appearance: White to light brown solid powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 516.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Kitano et al (2000) Long-lasting cholecystokinin2 receptor blockade after a single subcutaneous injection of YF476 or YM022. Br.J.Pharmacol. 130 699. PMID: 10821801.

2. Beinborn et al (1998) Small synthetic ligands of the cholecystokinin-B/gastrin receptor can mimic the function of endogenous peptide hormones. Yale J.Biol.Med. 71 337. PMID: 10461364.