LYN-1604 free base

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MedKoo CAT#: 525868

CAS#: 2088939-99-3 (free base)

Description: LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis. LYN-1604 could induce cell death, associated with autophagy by the ULK complex (ULK1-mATG13-FIP200-ATG101) in MDA-MB-231 cells. To further explore LYN-1604-induced autophagic mechanisms, we found some potential ULK1 interactors, such as ATF3, RAD21, and caspase3, by performing comparative microarray analysis. LYN-1604 induced cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.


Price and Availability

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Pricing updated 2020-10-26. Prices are subject to change without notice.

LYN-1604 free base is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 525868
Name: LYN-1604 free base
CAS#: 2088939-99-3 (free base)
Chemical Formula: C33H43Cl2N3O2
Exact Mass: 583.2732
Molecular Weight: 584.626
Elemental Analysis: C, 67.80; H, 7.41; Cl, 12.13; N, 7.19; O, 5.47


Related CAS #: 2088939-99-3 (free base)   2216753-86-3 (HCl)    

Synonym: LYN-1604; LYN 1604; LYN1604; LYN-1604 free base

IUPAC/Chemical Name: 1-{4-[2-(2,4-Dichloro-phenyl)-2-(naphthalen-2-ylmethoxy)-ethyl]-piperazin-1-yl}-2-diisobutylamino-ethanone

InChi Key: DVNVYWLKGWAELS-UHFFFAOYSA-N

InChi Code: InChI=1S/C33H43Cl2N3O2/c1-24(2)19-37(20-25(3)4)22-33(39)38-15-13-36(14-16-38)21-32(30-12-11-29(34)18-31(30)35)40-23-26-9-10-27-7-5-6-8-28(27)17-26/h5-12,17-18,24-25,32H,13-16,19-23H2,1-4H3

SMILES Code: CC(C)CN(CC(N1CCN(CC(C2=CC=C(Cl)C=C2Cl)OCC3=CC=C4C=CC=CC4=C3)CC1)=O)CC(C)C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

ULK1 (unc-51 like autophagy activating kinase 1) is well known to be required to initiate the macroautophagy/autophagy process, and thus activation of ULK1-modulating autophagy/autophagy-associated cell death (ACD) may be a possible therapeutic strategy in triple negative breast cancer (TNBC).


References

1: Ma S, Yu Z, Feng S, Chen H, Chen H, Lu X. Corneal autophagy and ocular surface
inflammation: A new perspective in dry eye. Exp Eye Res. 2019 Apr 21;184:126-134.
doi: 10.1016/j.exer.2019.04.023. [Epub ahead of print] PubMed PMID: 31018117.

2: Zhang L, Fu L, Zhang S, Zhang J, Zhao Y, Zheng Y, He G, Yang S, Ouyang L, Liu
B. Discovery of a small molecule targeting ULK1-modulated cell death of triple
negative breast cancer in vitro and in vivo. Chem Sci. 2017 Apr 1;8(4):2687-2701.
doi: 10.1039/c6sc05368h. Epub 2017 Jan 9. PubMed PMID: 28553505; PubMed Central
PMCID: PMC5433508.

3: Ouyang L, Zhang L, Fu L, Liu B. A small-molecule activator induces
ULK1-modulating autophagy-associated cell death in triple negative breast cancer.
Autophagy. 2017 Apr 3;13(4):777-778. doi: 10.1080/15548627.2017.1283470. Epub
2017 Feb 6. PubMed PMID: 28165887; PubMed Central PMCID: PMC5388211.