WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525804

CAS#: 309735-05-5

Description: ABC-1 is a novel biofilm formation inhibitor, downregulating SpA expression, preventing bacterial biofilm formation in multiple bacterial pathogens, including Staphylococcus aureus without affecting the growth of bacteria.

Chemical Structure

CAS# 309735-05-5

Theoretical Analysis

MedKoo Cat#: 525804
Name: ABC-1
CAS#: 309735-05-5
Chemical Formula: C16H16N2OS
Exact Mass: 284.0983
Molecular Weight: 284.377
Elemental Analysis: C, 67.58; H, 5.67; N, 9.85; O, 5.63; S, 11.27

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: ABC-1; ABC 1; ABC1;

IUPAC/Chemical Name: 5-Methoxy-2-[(4-methylbenzyl)sulfanyl]-1H-benzimidazole


InChi Code: InChI=1S/C16H16N2OS/c1-11-3-5-12(6-4-11)10-20-16-17-14-8-7-13(19-2)9-15(14)18-16/h3-9H,10H2,1-2H3,(H,17,18)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 284.377 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Krupkova O, Hlavna M, Amir Tahmasseb J, Zvick J, Kunz D, Ito K, Ferguson SJ, Wuertz-Kozak K. An Inflammatory Nucleus Pulposus Tissue Culture Model to Test Molecular Regenerative Therapies: Validation with Epigallocatechin 3-Gallate. Int J Mol Sci. 2016 Sep 27;17(10). pii: E1640. PubMed PMID: 27689996; PubMed Central PMCID: PMC5085673.

2: K A S, Venkata Subbaiah KC, Lavanya R, Chandrasekhar K, Chamarti NR, Kumar MS, Wudayagiri R, Valluru L. Design, Synthesis and Biological Evaluation of Novel Phosphorylated Abacavir Derivatives as Antiviral Agents Against Newcastle Disease Virus Infection in Chicken. Appl Biochem Biotechnol. 2016 Sep;180(2):361-81. doi: 10.1007/s12010-016-2104-x. Epub 2016 May 3. PubMed PMID: 27142273.

3: Shrestha L, Kayama S, Sasaki M, Kato F, Hisatsune J, Tsuruda K, Koizumi K, Tatsukawa N, Yu L, Takeda K, Sugai M. Inhibitory effects of antibiofilm compound 1 against Staphylococcus aureus biofilms. Microbiol Immunol. 2016 Mar;60(3):148-59. doi: 10.1111/1348-0421.12359. PubMed PMID: 26786482.

4: Wu TC, Lin YC, Chen HL, Huang PR, Liu SY, Yeh SL. The enhancing effect of genistein on apoptosis induced by trichostatin A in lung cancer cells with wild type p53 genes is associated with upregulation of histone acetyltransferase. Toxicol Appl Pharmacol. 2016 Feb 1;292:94-102. doi: 10.1016/j.taap.2015.12.028. Epub 2016 Jan 6. PubMed PMID: 26768552.

5: Herbst-Kralovetz MM. Overcoming barriers in the mucosal delivery of virus-like particle-based vaccines. Ther Deliv. 2014 Jul;5(7):741-4. doi: 10.4155/tde.14.52. PubMed PMID: 25287380.

6: Yuksel Durmaz Y, Vlaisavljevich E, Xu Z, ElSayed M. Development of nanodroplets for histotripsy-mediated cell ablation. Mol Pharm. 2014 Oct 6;11(10):3684-95. doi: 10.1021/mp500419w. Epub 2014 Sep 15. PubMed PMID: 25137434.

7: Jalan AA, Jochim KA, Hartgerink JD. Rational design of a non-canonical "sticky-ended" collagen triple helix. J Am Chem Soc. 2014 May 28;136(21):7535-8. doi: 10.1021/ja5001246. Epub 2014 May 14. PubMed PMID: 24828884.

8: Kulshrestha A, Sharma V, Singh R, Salotra P. Comparative transcript expression analysis of miltefosine-sensitive and miltefosine-resistant Leishmania donovani. Parasitol Res. 2014 Mar;113(3):1171-84. doi: 10.1007/s00436-014-3755-6. Epub 2014 Jan 22. PubMed PMID: 24449447.

9: Murphy RA, Register TC, Shively CA, Carr JJ, Ge Y, Heilbrun ME, Cummings SR, Koster A, Nevitt MC, Satterfield S, Tylvasky FA, Strotmeyer ES, Newman AB, Simonsick EM, Scherzinger A, Goodpaster BH, Launer LJ, Eiriksdottir G, Sigurdsson S, Sigurdsson G, Gudnason V, Lang TF, Kritchevsky SB, Harris TB. Adipose tissue density, a novel biomarker predicting mortality risk in older adults. J Gerontol A Biol Sci Med Sci. 2014 Jan;69(1):109-17. doi: 10.1093/gerona/glt070. Epub 2013 May 24. PubMed PMID: 23707956; PubMed Central PMCID: PMC3859360.

10: Zhang C, He X, Li H, Wang G. Chondroitinase ABC plus bone marrow mesenchymal stem cells for repair of spinal cord injury. Neural Regen Res. 2013 Apr 15;8(11):965-74. doi: 10.3969/j.issn.1673-5374.2013.11.001. PubMed PMID: 25206389; PubMed Central PMCID: PMC4145889.

11: Christofolini DM, Meloni VA, Ramos MA, Oliveira MM, de Mello CB, Pellegrino R, Takeno SS, Melaragno MI. Autistic disorder phenotype associated to a complex 15q intrachromosomal rearrangement. Am J Med Genet B Neuropsychiatr Genet. 2012 Oct;159B(7):823-8. doi: 10.1002/ajmg.b.32089. Epub 2012 Aug 22. PubMed PMID: 22911893.

12: Pritchard KI, Sousa B. ABC 1 (1st International consensus guidelines for advanced breast cancer): a positive step. Breast. 2012 Jun;21(3):225-6. doi: 10.1016/j.breast.2012.05.010. PubMed PMID: 22709870.

13: Wong RP, Davis TM. In vitro antimalarial activity and drug interactions of fenofibric acid. Antimicrob Agents Chemother. 2012 Jun;56(6):2814-8. doi: 10.1128/AAC.05076-11. Epub 2012 Mar 19. PubMed PMID: 22430967; PubMed Central PMCID: PMC3370754.

14: Cardoso F, Costa A, Norton L, Cameron D, Cufer T, Fallowfield L, Francis P, Gligorov J, Kyriakides S, Lin N, Pagani O, Senkus E, Thomssen C, Aapro M, Bergh J, Di Leo A, El Saghir N, Ganz PA, Gelmon K, Goldhirsch A, Harbeck N, Houssami N, Hudis C, Kaufman B, Leadbeater M, Mayer M, Rodger A, Rugo H, Sacchini V, Sledge G, van't Veer L, Viale G, Krop I, Winer E. 1st International consensus guidelines for advanced breast cancer (ABC 1). Breast. 2012 Jun;21(3):242-52. doi: 10.1016/j.breast.2012.03.003. Epub 2012 Mar 16. PubMed PMID: 22425534.

15: Sambanthamoorthy K, Gokhale AA, Lao W, Parashar V, Neiditch MB, Semmelhack MF, Lee I, Waters CM. Identification of a novel benzimidazole that inhibits bacterial biofilm formation in a broad-spectrum manner. Antimicrob Agents Chemother. 2011 Sep;55(9):4369-78. doi: 10.1128/AAC.00583-11. Epub 2011 Jun 27. PubMed PMID: 21709104; PubMed Central PMCID: PMC3165298.

16: Watanabe T, Miura T, Degawa Y, Fujita Y, Inoue M, Kawaguchi M, Furihata C. Comparison of lung cancer cell lines representing four histopathological subtypes with gene expression profiling using quantitative real-time PCR. Cancer Cell Int. 2010 Jan 21;10:2. doi: 10.1186/1475-2867-10-2. PubMed PMID: 20142997; PubMed Central PMCID: PMC2817686.

17: Rabito EI, Mialich MS, Martínez EZ, García RW, Jordao AA Jr, Marchini JS. Validation of predictive equations for weight and height using a metric tape. Nutr Hosp. 2008 Nov-Dec;23(6):614-8. PubMed PMID: 19132271.

18: Greenes RA, Panchanathan S, Patel V, Silverman H, Shortliffe EH. Biomedical informatics in the desert--a new and unique program at Arizona State University. Yearb Med Inform. 2008:150-6. PubMed PMID: 18660889.

19: Nikulina EM, Arrillaga-Romany I, Miczek KA, Hammer RP Jr. Long-lasting alteration in mesocorticolimbic structures after repeated social defeat stress in rats: time course of mu-opioid receptor mRNA and FosB/DeltaFosB immunoreactivity. Eur J Neurosci. 2008 May;27(9):2272-84. doi: 10.1111/j.1460-9568.2008.06176.x. PubMed PMID: 18445218; PubMed Central PMCID: PMC2442756.

20: Potard V, Rey D, Mokhtari S, Frixon-Marin V, Pradier C, Rozenbaum W, Brun-Vezinet F, Costagliola D; French Hospital Database on HIV, ANRS C04.. First-line highly active antiretroviral regimens in 2001-2002 in the French Hospital Database on HIV: combination prescribed and biological outcomes. Antivir Ther. 2007;12(3):317-24. PubMed PMID: 17591021.