VU0463841

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MedKoo CAT#: 532948

CAS#: 1439095-16-5

Description: VU0463841 is a negative allosteric modulators of mGlu5.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-10-29. Prices are subject to change without notice.

VU0463841 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 532948
Name: VU0463841
CAS#: 1439095-16-5
Chemical Formula: C13H8ClFN4O
Exact Mass: 290.037
Molecular Weight: 290.68
Elemental Analysis: C, 53.72; H, 2.77; Cl, 12.20; F, 6.54; N, 19.27; O, 5.50


Synonym: VU0463841, VU-0463841, VU 0463841

IUPAC/Chemical Name: 1-(5-chloropyridin-2-yl)-3-(3-cyano-5-fluorophenyl)urea

InChi Key: KDANLHLWAYNCMV-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H8ClFN4O/c14-9-1-2-12(17-7-9)19-13(20)18-11-4-8(6-16)3-10(15)5-11/h1-5,7H,(H2,17,18,19,20)

SMILES Code: O=C(NC1=CC(F)=CC(C#N)=C1)NC2=NC=C(Cl)C=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Amato RJ, Felts AS, Rodriguez AL, Venable DF, Morrison RD, Byers FW, Daniels JS, Niswender CM, Conn PJ, Lindsley CW, Jones CK, Emmitte KA. Substituted 1-Phenyl-3-(pyridin-2-yl)urea negative allosteric modulators of mGlu5: discovery of a new tool compound VU0463841 with activity in rat models of cocaine addiction. ACS Chem Neurosci. 2013 Aug 21;4(8):1217-28. doi: 10.1021/cn400070k. Epub 2013 May 29. PubMed PMID: 23682684; PubMed Central PMCID: PMC3750677.