BT173

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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525749

CAS#: N/A

Description: BT173 is a novel inhibitor of homeodomain interacting protein kinase 2 (HIPK2 ), attenuating renal fibrosis through suppression of the TGF-ß1/Smad3 pathway.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-04-07. Prices are subject to change without notice.

BT173 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 525749
Name: BT173
CAS#: N/A
Chemical Formula: C18H12BrN3O2
Exact Mass: 381.0113
Molecular Weight: 382.217
Elemental Analysis: C, 56.56; H, 3.16; Br, 20.91; N, 10.99; O, 8.37


Synonym: BT173

IUPAC/Chemical Name: 3-[3-(4-Bromo-phenyl)-[1,2,4]oxadiazol-5-yl]-7-methoxy-quinoline

InChi Key: IZEKVHBNUXXZFE-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H12BrN3O2/c1-23-15-7-4-12-8-13(10-20-16(12)9-15)18-21-17(22-24-18)11-2-5-14(19)6-3-11/h2-10H,1H3

SMILES Code: COC1=CC=C2C=C(C3=NC(C4=CC=C(Br)C=C4)=NO3)C=NC2=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Liu R, Das B, Xiao W, Li Z, Li H, Lee K, He JC. A Novel Inhibitor of Homeodomain Interacting Protein Kinase 2 Mitigates Kidney Fibrosis through Inhibition of the TGF-β1/Smad3 Pathway. J Am Soc Nephrol. 2017 Feb 20. pii: ASN.2016080841. doi: 10.1681/ASN.2016080841. [Epub ahead of print] PubMed PMID: 28220029.