WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 532881
Description: VPC171 is a positive allosteric modulator (PAM) of the adenosine A1 receptor (A1R). PAMs of the A1R are being investigated as a novel treatment approach for neuropathic pain.
MedKoo Cat#: 532881
Chemical Formula: C18H12F3NOS
Exact Mass: 347.0592
Molecular Weight: 347.36
Elemental Analysis: C, 62.24; H, 3.48; F, 16.41; N, 4.03; O, 4.61; S, 9.23
Synonym: VPC171; VPC 171; VPC-171;
IUPAC/Chemical Name: [2-amino-4-[3-(trifluoromethyl)phenyl]thiophen-3-yl]-phenylmethanone
InChi Key: HNHLVOBHWXLIGP-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H12F3NOS/c19-18(20,21)13-8-4-7-12(9-13)14-10-24-17(22)15(14)16(23)11-5-2-1-3-6-11/h1-10H,22H2
SMILES Code: O=C(C1=C(N)SC=C1C2=CC=CC(C(F)(F)F)=C2)C3=CC=CC=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 347.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Aurelio L, Valant C, Flynn BL, Sexton PM, Christopoulos A, Scammells PJ. (2009) Allosteric modulators of the adenosine A1 receptor: synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes. J. Med. Chem., 52 (14): 4543-7. [PMID:19514747]
2. Imlach WL, Bhola RF, May LT, Christopoulos A, Christie MJ. (2015) A Positive Allosteric Modulator of the Adenosine A1 Receptor Selectively Inhibits Primary Afferent Synaptic Transmission in a Neuropathic Pain Model. Mol. Pharmacol., 88 (3): 460-8. [PMID:26104547]