VPC171
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532881

CAS#: 1018830-99-3

Description: VPC171 is a positive allosteric modulator (PAM) of the adenosine A1 receptor (A1R). PAMs of the A1R are being investigated as a novel treatment approach for neuropathic pain.


Chemical Structure

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VPC171
CAS# 1018830-99-3

Theoretical Analysis

MedKoo Cat#: 532881
Name: VPC171
CAS#: 1018830-99-3
Chemical Formula: C18H12F3NOS
Exact Mass: 347.0592
Molecular Weight: 347.36
Elemental Analysis: C, 62.24; H, 3.48; F, 16.41; N, 4.03; O, 4.61; S, 9.23

Price and Availability

Size Price Availability Quantity
10.0mg USD 350.0 2 Weeks
50.0mg USD 1010.0 2 Weeks
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Synonym: VPC171; VPC 171; VPC-171;

IUPAC/Chemical Name: [2-amino-4-[3-(trifluoromethyl)phenyl]thiophen-3-yl]-phenylmethanone

InChi Key: HNHLVOBHWXLIGP-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H12F3NOS/c19-18(20,21)13-8-4-7-12(9-13)14-10-24-17(22)15(14)16(23)11-5-2-1-3-6-11/h1-10H,22H2

SMILES Code: O=C(C1=C(N)SC=C1C2=CC=CC(C(F)(F)F)=C2)C3=CC=CC=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 347.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Aurelio L, Valant C, Flynn BL, Sexton PM, Christopoulos A, Scammells PJ. (2009) Allosteric modulators of the adenosine A1 receptor: synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes. J. Med. Chem., 52 (14): 4543-7. [PMID:19514747]

2. Imlach WL, Bhola RF, May LT, Christopoulos A, Christie MJ. (2015) A Positive Allosteric Modulator of the Adenosine A1 Receptor Selectively Inhibits Primary Afferent Synaptic Transmission in a Neuropathic Pain Model. Mol. Pharmacol., 88 (3): 460-8. [PMID:26104547]

VPC171

10.0mg / USD 350.0