WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532871

CAS#: 230961-08-7

Description: UK-356618 is a matrix metalloproteinase-3 (MMP-3) inhibitor.

Chemical Structure

CAS# 230961-08-7

Theoretical Analysis

MedKoo Cat#: 532871
Name: UK-356618
CAS#: 230961-08-7
Chemical Formula: C34H43N3O4
Exact Mass: 557.3254
Molecular Weight: 557.74
Elemental Analysis: C, 73.22; H, 7.77; N, 7.53; O, 11.47

Price and Availability

Size Price Availability Quantity
5.0mg USD 260.0 2 Weeks
10.0mg USD 475.0 2 Weeks
25.0mg USD 830.0 2 Weeks
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Synonym: UK-356618, UK356618, UK356618

IUPAC/Chemical Name: (2R)-N-[(2S)-3,3-dimethyl-1-oxo-1-[[(1R)-1-phenylethyl]amino]butan-2-yl]-N'-hydroxy-2-[3-(3-methyl-4-phenylphenyl)propyl]butanediamide


InChi Code: InChI=1S/C34H43N3O4/c1-23-21-25(19-20-29(23)27-16-10-7-11-17-27)13-12-18-28(22-30(38)37-41)32(39)36-31(34(3,4)5)33(40)35-24(2)26-14-8-6-9-15-26/h6-11,14-17,19-21,24,28,31,41H,12-13,18,22H2,1-5H3,(H,35,40)(H,36,39)(H,37,38)/t24-,28-,31-/m1/s1

SMILES Code: O=C(N[C@@H](C(C)(C)C)C(N[C@@H](C1=CC=CC=C1)C)=O)[C@H](CCCC2=CC=C(C3=CC=CC=C3)C(C)=C2)CC(NO)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 557.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Hafez S, Abdelsaid M, El-Shafey S, Johnson MH, Fagan SC, Ergul A. Matrix Metalloprotease 3 Exacerbates Hemorrhagic Transformation and Worsens Functional Outcomes in Hyperglycemic Stroke. Stroke. 2016 Mar;47(3):843-51. doi: 10.1161/STROKEAHA.115.011258. Epub 2016 Feb 2. PubMed PMID: 26839355; PubMed Central PMCID: PMC4766051.