W-34

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525598

CAS#: N/A

Description: W-34 is a novel potent CDK8 inhibitor.


Chemical Structure

img
W-34
CAS# N/A

Theoretical Analysis

MedKoo Cat#: 525598
Name: W-34
CAS#: N/A
Chemical Formula: C22H22Cl2FN5OS
Exact Mass: 493.0906
Molecular Weight: 494.4104
Elemental Analysis: C, 53.45; H, 4.49; Cl, 14.34; F, 3.84; N, 14.17; O, 3.24; S, 6.48

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: W-34, W 34, W34

IUPAC/Chemical Name: 1-(3,4-Dichloro-phenyl)-3-{1-[5-(4-fluoro-benzyl)-[1,2,4]thiadiazol-3-yl]-piperidin-4-ylmethyl}-urea

InChi Key: UXENHMYWTQJELH-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H22Cl2FN5OS/c23-18-6-5-17(12-19(18)24)27-22(31)26-13-15-7-9-30(10-8-15)21-28-20(32-29-21)11-14-1-3-16(25)4-2-14/h1-6,12,15H,7-11,13H2,(H2,26,27,31)

SMILES Code: O=C(NCC1CCN(C2=NSC(CC3=CC=C(F)C=C3)=N2)CC1)NC4=CC=C(Cl)C(Cl)=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 494.4104 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Wang T, Yang Z, Zhang Y, Yan W, Wang F, He L, Zhou Y, Chen L. Discovery of novel CDK8 inhibitors using multiple crystal structures in docking-based virtual screening. Eur J Med Chem. 2017 Mar 31;129:275-286. doi: 10.1016/j.ejmech.2017.02.020. Epub 2017 Feb 9. PubMed PMID: 28231524.

2: Xavier JG, Geremias TC, Montero JF, Vahey BR, Benfatti CA, Souza JC, Magini RS, Pimenta AL. Lactam inhibiting Streptococcus mutans growth on titanium. Mater Sci Eng C Mater Biol Appl. 2016 Nov 1;68:837-41. doi: 10.1016/j.msec.2016.07.013. Epub 2016 Jul 7. PubMed PMID: 27524086.

3: Fujimoto T, Sasaki Y, Wakabayashi H, Sengoku Y, Tsubakimoto S, Nishiyasu T. Maximal workload but not peak oxygen uptake is decreased during immersed incremental exercise at cooler temperatures. Eur J Appl Physiol. 2016 Sep;116(9):1819-27. doi: 10.1007/s00421-016-3438-3. Epub 2016 Jul 25. PubMed PMID: 27456478.

4: Elik A, Yanık DK, Maskan M, Göğüş F. Influence of three different concentration techniques on evaporation rate, color and phenolics content of blueberry juice. J Food Sci Technol. 2016 May;53(5):2389-95. doi: 10.1007/s13197-016-2213-0. Epub 2016 May 5. PubMed PMID: 27407205; PubMed Central PMCID: PMC4921090.

5: Adamczyk J, Deregowska A, Skoneczny M, Skoneczna A, Natkanska U, Kwiatkowska A, Rawska E, Potocki L, Kuna E, Panek A, Lewinska A, Wnuk M. Copy number variations of genes involved in stress responses reflect the redox state and DNA damage in brewing yeasts. Cell Stress Chaperones. 2016 Sep;21(5):849-64. doi: 10.1007/s12192-016-0710-8. Epub 2016 Jun 14. PubMed PMID: 27299603; PubMed Central PMCID: PMC5003802.

6: Macedo JP, Pereira J, Vahey BR, Henriques B, Benfatti CA, Magini RS, López-López J, Souza JC. Morse taper dental implants and platform switching: The new paradigm in oral implantology. Eur J Dent. 2016 Jan-Mar;10(1):148-54. doi: 10.4103/1305-7456.175677. Review. PubMed PMID: 27011755; PubMed Central PMCID: PMC4784146.

7: Negriff S, Blankson AN, Trickett PK. Pubertal Timing and Tempo: Associations With Childhood Maltreatment. J Res Adolesc. 2015 Jun 1;25(2):201-213. PubMed PMID: 26146470; PubMed Central PMCID: PMC4489155.

8: Dębska M, Kretowicz P, Tarasiuk A, Dangel J, Dębski R. Successful intrauterine treatment and good long-term outcome in an extremely severe case of fetal hemolytic disease. J Ultrason. 2014 Jun;14(57):217-22. doi: 10.15557/JoU.2014.0021. Epub 2014 Jun 30. PubMed PMID: 26673879; PubMed Central PMCID: PMC4579700.

9: Navazesh M, Rich SK, Keim RG. Triple jump examination evaluation of faculty examiners by dental student examinees. J Dent Educ. 2014 May;78(5):714-22. PubMed PMID: 24789831.

10: Méjean C, Deglaire A, Kesse-Guyot E, Hercberg S, Schlich P, Castetbon K. Association between intake of nutrients and food groups and liking for fat (The Nutrinet-Santé Study). Appetite. 2014 Jul;78:147-55. doi: 10.1016/j.appet.2014.03.017. Epub 2014 Mar 27. PubMed PMID: 24681104.

11: Yamamoto Y, Shirakabe A, Hata N, Kobayashi N, Shinada T, Tomita K, Yamamoto M, Tsurumi M, Matsushita M, Okazaki H, Yokoyama S, Asai K, Mizuno K, Shimizu W. Seasonal variation in patients with acute heart failure: prognostic impact of admission in the summer. Heart Vessels. 2015 Mar;30(2):193-203. doi: 10.1007/s00380-013-0461-8. Epub 2014 Jan 8. PubMed PMID: 24398627.

12: Navazesh M, Rich SK, Chopiuk NB, Keim RG. Triple jump examinations for dental student assessment. J Dent Educ. 2013 Oct;77(10):1315-20. PubMed PMID: 24098035.

13: Hoshino D, Yoshida Y, Holloway GP, Lally J, Hatta H, Bonen A. Clenbuterol, a β2-adrenergic agonist, reciprocally alters PGC-1 alpha and RIP140 and reduces fatty acid and pyruvate oxidation in rat skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2012 Feb 1;302(3):R373-84. doi: 10.1152/ajpregu.00183.2011. Epub 2011 Nov 9. PubMed PMID: 22071161.

14: Son-Hing JP, Poe-Kochert C, Thompson GH, Potzman J, Tripi PA. Intrathecal morphine analgesia in idiopathic scoliosis surgery: does sex or racial group affect optimal dosing? J Pediatr Orthop. 2011 Jul-Aug;31(5):489-95. doi: 10.1097/BPO.0b013e3182203988. PubMed PMID: 21654454.

15: Cho GC, Chee WW, Tan DT. Dental students' ability to evaluate themselves in fixed prosthodontics. J Dent Educ. 2010 Nov;74(11):1237-42. PubMed PMID: 21045229.

16: Joyce GF. Understanding Primary Nonadherence. Am J Pharm Benefits. 2010 Apr 26;2(2):111-118. PubMed PMID: 24466385; PubMed Central PMCID: PMC3898835.

17: Kawamoto C, Yamauchi A, Baba Y, Kaneko K, Yakabi K. Measurement of intrahepatic pressure during radiofrequency ablation in porcine liver. J Gastroenterol. 2010 Apr;45(4):435-42. doi: 10.1007/s00535-009-0156-1. Epub 2009 Nov 20. PubMed PMID: 19936601.

18: Bryant CS, Kumar S, Shah JP, Mahdi H, Ali-Fehmi R, Munkarah AR, Deppe G, Morris RT. Racial disparities in survival among patients with germ cell tumors of the ovary--United States. Gynecol Oncol. 2009 Sep;114(3):437-41. doi: 10.1016/j.ygyno.2009.05.039. Epub 2009 Jun 26. PubMed PMID: 19560191.

19: Astaneh R, Erfan M, Moghimi H, Mobedi H. Changes in morphology of in situ forming PLGA implant prepared by different polymer molecular weight and its effect on release behavior. J Pharm Sci. 2009 Jan;98(1):135-45. doi: 10.1002/jps.21415. PubMed PMID: 18493999.

20: Tarqui-Mamani C, Barreda-Gallegos A. [Choice of and preference for home child-birth in Callao, Perú]. Rev Salud Publica (Bogota). 2006 Sep-Dec;8(3):214-22. Spanish. PubMed PMID: 17269221.