WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 532859
Description: UCCF-853 is an activator of the CFTR Cl- channel which may be useful for therapy of cystic fibrosis.
MedKoo Cat#: 532859
Chemical Formula: C14H8ClF3N2O
Exact Mass: 312.0277
Molecular Weight: 312.68
Elemental Analysis: C, 53.78; H, 2.58; Cl, 11.34; F, 18.23; N, 8.96; O, 5.12
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
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Synonym: UCCF-853, UCCF 853, UCCF853
IUPAC/Chemical Name: 1-(3-chlorophenyl)-5-(trifluoromethyl)-2,3-dihydro-1H-1,3-benzodiazol-2-one
InChi Key: NMPJFFWYEIIGFW-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H8ClF3N2O/c15-9-2-1-3-10(7-9)20-12-5-4-8(14(16,17)18)6-11(12)19-13(20)21/h1-7H,(H,19,21)
SMILES Code: O=C1N(C2=CC=CC(Cl)=C2)C3=CC=C(C(F)(F)F)C=C3N1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 312.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Caci E, Folli C, Zegarra-Moran O, Ma T, Springsteel MF, Sammelson RE, Nantz MH, Kurth MJ, Verkman AS, Galietta LJ. CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds. Am J Physiol Lung Cell Mol Physiol. 2003 Jul;285(1):L180-8. Epub 2003 Mar 21. PubMed PMID: 12651632.