WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532849

CAS#: 82657-23-6

Description: U-47700 is a selective µ-opioid receptor agonist (Kd = 5.3 and 910 nM for µ- and κ-opioid receptors, respectively, in guinea pig brain) that is 7.5-fold more potent than morphine. U-47700 is an analytical reference material that is structurally categorized as an opioid. NOTE: U-47700 was discontinued (Controlled substance)

Chemical Structure

CAS# 82657-23-6

Theoretical Analysis

MedKoo Cat#: 532849
Name: U-47700
CAS#: 82657-23-6
Chemical Formula: C16H22Cl2N2O
Exact Mass: 328.1109
Molecular Weight: 329.27
Elemental Analysis: C, 58.37; H, 6.74; Cl, 21.53; N, 8.51; O, 4.86

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: U-47700, U 47700, U47700

IUPAC/Chemical Name: 3,4-dichloro-N-[(1R,2R)-2-(dimethylamino)cyclohexyl]-N-methylbenzamide


InChi Code: InChI=1S/C16H22Cl2N2O/c1-19(2)14-6-4-5-7-15(14)20(3)16(21)11-8-9-12(17)13(18)10-11/h8-10,14-15H,4-7H2,1-3H3/t14-,15-/m1/s1

SMILES Code: O=C(N([C@H]1[C@H](N(C)C)CCCC1)C)C2=CC=C(Cl)C(Cl)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 329.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Dziadosz M, Klintschar M, Teske J. Postmortem concentration distribution in fatal cases involving the synthetic opioid U-47700. Int J Legal Med. 2017 Apr 11. doi: 10.1007/s00414-017-1593-7. [Epub ahead of print] PubMed PMID: 28401304.

2: Metushi I, Schneir A, Fitzgerald R. Identification of Novel Synthetic Opioid U-47700 through a Broad Screen Time of Flight High-Resolution Mass Spectrometry Method. Am J Clin Pathol. 2017 Mar 1;147(suppl_2):S168. doi: 10.1093/ajcp/aqw191.035. PubMed PMID: 28339954.

3: Fleming SW, Cooley JC, Johnson L, Frazee CC, Domanski K, Kleinschmidt K, Garg U. Analysis of U-47700, a Novel Synthetic Opioid, in Human Urine by LC-MS-MS and LC-QToF. J Anal Toxicol. 2017 Apr 1;41(3):173-180. doi: 10.1093/jat/bkw131. PubMed PMID: 28035035.

4: Drug Enforcement Administration, Department of Justice.. Schedules of Controlled Substances: Temporary Placement of U-47700 Into Schedule I. Final order. Fed Regist. 2016 Nov 14;81(219):79389-93. PubMed PMID: 27905978.

5: McIntyre IM, Gary RD, Joseph S, Stabley R. A Fatality Related to the Synthetic Opioid U-47700: Postmortem Concentration Distribution. J Anal Toxicol. 2017 Mar 1;41(2):158-160. doi: 10.1093/jat/bkw124. PubMed PMID: 27798077.

6: Schneir A, Metushi IG, Fitzgerald RL. U-47700 Reply. Clin Toxicol (Phila). 2017 Jan;55(1):73. doi: 10.1080/15563650.2016.1239108. Epub 2016 Oct 17. PubMed PMID: 27744720.

7: Vo KT, van Wijk XM, Wu AH, Lynch KL, Ho RY. Synthetic agents off the darknet: a case of U-47700 and phenazepam abuse. Clin Toxicol (Phila). 2017 Jan;55(1):71-72. doi: 10.1080/15563650.2016.1240806. Epub 2016 Oct 13. PubMed PMID: 27736261.

8: Mohr AL, Friscia M, Papsun D, Kacinko SL, Buzby D, Logan BK. Analysis of Novel Synthetic Opioids U-47700, U-50488 and Furanyl Fentanyl by LC-MS/MS in Postmortem Casework. J Anal Toxicol. 2016 Nov;40(9):709-717. Epub 2016 Sep 1. PubMed PMID: 27590036.

9: Jones MJ, Hernandez BS, Janis GC, Stellpflug SJ. A case of U-47700 overdose with laboratory confirmation and metabolite identification. Clin Toxicol (Phila). 2017 Jan;55(1):55-59. doi: 10.1080/15563650.2016.1209767. Epub 2016 Aug 23. Erratum in: Clin Toxicol (Phila). 2017 Jan;55(1):76. PubMed PMID: 27549165.

10: Armenian P, Olson A, Anaya A, Kurtz A, Ruegner R, Gerona RR. Fentanyl and a Novel Synthetic Opioid U-47700 Masquerading as Street "Norco" in Central California: A Case Report. Ann Emerg Med. 2017 Jan;69(1):87-90. doi: 10.1016/j.annemergmed.2016.06.014. Epub 2016 Jul 26. PubMed PMID: 27473610.

11: Schneir A, Metushi IG, Sloane C, Benaron DJ, Fitzgerald RL. Near death from a novel synthetic opioid labeled U-47700: emergence of a new opioid class. Clin Toxicol (Phila). 2017 Jan;55(1):51-54. doi: 10.1080/15563650.2016.1209764. Epub 2016 Jul 22. PubMed PMID: 27448790.

12: Domanski K, Kleinschmidt KC, Schulte JM, Fleming S, Frazee C, Menendez A, Tavakoli K. Two cases of intoxication with new synthetic opioid, U-47700. Clin Toxicol (Phila). 2017 Jan;55(1):46-50. doi: 10.1080/15563650.2016.1209763. Epub 2016 Jul 19. PubMed PMID: 27432224.

13: Ruan X, Chiravuri S, Kaye AD. Comparing fatal cases involving U-47700. Forensic Sci Med Pathol. 2016 Sep;12(3):369-71. doi: 10.1007/s12024-016-9795-8. Epub 2016 Jul 16. PubMed PMID: 27421264.

14: Coopman V, Blanckaert P, Van Parys G, Van Calenbergh S, Cordonnier J. A case of acute intoxication due to combined use of fentanyl and 3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700). Forensic Sci Int. 2016 Sep;266:68-72. doi: 10.1016/j.forsciint.2016.05.001. Epub 2016 May 13. PubMed PMID: 27235591.

15: Elliott SP, Brandt SD, Smith C. The first reported fatality associated with the synthetic opioid 3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700) and implications for forensic analysis. Drug Test Anal. 2016 Aug;8(8):875-9. doi: 10.1002/dta.1984. Epub 2016 May 27. PubMed PMID: 27232154.