WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 532848
Description: U46619 is a PGH2 (TXA2) analog that is a potent and stable thromboxane A2 (TP) receptor agonist (EC50 = 0.035 μM). U46619 potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. It activates ERK-1 and ERK-2 in HEK 293 cells expressing TPα and TPβ receptors.
MedKoo Cat#: 532848
Chemical Formula: C21H34O4
Exact Mass: 350.2457
Molecular Weight: 350.5
Elemental Analysis: C, 71.96; H, 9.78; O, 18.26
This product is not in stock, which may be available by custom synthesis.
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Synonym: U46619, U-46619, U 46619
IUPAC/Chemical Name: (Z)-7-[(1S,4R,5R,6S)-5-[(E,3S)-3-hydroxyoct-1-enyl]-3-oxabicyclo[2.2.1]heptan-6-yl]hept-5-enoic acid
InChi Key: LQANGKSBLPMBTJ-BRSNVKEHSA-N
InChi Code: InChI=1S/C21H34O4/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16-,17+,18+,19-,20-/m1/s1
SMILES Code: O=C(O)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)[C@]2([H])OC[C@@]1([H])C2
Appearance: Clear oil
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 350.5 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Miggin and Kinsella (2002) Regulation of extracellular signal-regulated kinase cascades by α- and β-isoforms of the human thromboxane A2 receptor. Mol.Pharmacol. 61 817. PMID: 11901221.
2. Morinelli et al (1987) Receptor-mediated effects of a PGH2 analogue (U 46619) on human platelets. Am.J.Physiol. 253 H1035. PMID: 3688248.