WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532817

CAS#: 1164462-05-8

Description: TG4-155 is a brain penetrant EP2 antagonist (KB = 2.4 nM) that is over 1000-fold less effective at EP4 (KB = 11.4 µM) and a panel of other receptors and channels. It blocks the induced expression of inflammatory markers in microglial cells

Chemical Structure

CAS# 1164462-05-8

Theoretical Analysis

MedKoo Cat#: 532817
Name: TG4-155
CAS#: 1164462-05-8
Chemical Formula: C23H26N2O4
Exact Mass: 394.1893
Molecular Weight: 394.47
Elemental Analysis: C, 70.03; H, 6.64; N, 7.10; O, 16.22

Price and Availability

Size Price Availability Quantity
50.0mg USD 250.0 Ready to ship
100.0mg USD 450.0 Ready to ship
200.0mg USD 850.0 Ready to ship
500.0mg USD 1650.0 Ready to ship
1.0g USD 2950.0 Ready to ship
2.0g USD 4650.0 Ready to ship
5.0g USD 6950.0 2 Weeks
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Synonym: TG4-155; TG-4-155; TG 4-155; TG4155; TG-4155; TG 4155;

IUPAC/Chemical Name: (E)-N-[2-(2-methylindol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)prop-2-enamide


InChi Code: InChI=1S/C23H26N2O4/c1-16-13-18-7-5-6-8-19(18)25(16)12-11-24-22(26)10-9-17-14-20(27-2)23(29-4)21(15-17)28-3/h5-10,13-15H,11-12H2,1-4H3,(H,24,26)/b10-9+


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMF 50.0 126.75
DMSO 68.36 173.3
Ethanol 5.96 15.11

Preparing Stock Solutions

The following data is based on the product molecular weight 394.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Majima, M.,Amano, H., and Hayashi, I. Prostanoid receptor signaling relevant to tumor growth and angiogenesis. Trends in Pharamacological Sciences 34(10), 524-529 (2003).

2. Jiang, J., and Dingledine, R. Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection. Trends in Pharamacological Sciences 34(7), 413-423 (2013).

3. Kawahara, K.,Hohjoh, H.,Inazumi, T., et al. Prostaglandin E2-induced inflammation: Relevance of prostaglandin E receptors. Biochimica et Biophysica Acta 1851(4), 414-421 (2015).


50.0mg / USD 250.0