WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 525405
Description: JNJ525 TFA salt is a novel inhibitor of TNFalpha, inhibiting protein function via an aggregation-based mechanism that is distinct from protein sequestration and denaturation mechanisms proposed for enzymes.
MedKoo Cat#: 525405
Name: JNJ525 TFA salt
Chemical Formula: C31H30N8
Exact Mass: 514.2593
Molecular Weight: 514.637
Elemental Analysis: C, 72.35; H, 5.88; N, 21.77
This product is not in stock, which may be available by custom synthesis.
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Synonym: JNJ525 TFA salt
IUPAC/Chemical Name: N4-Benzyl-N4-[3'-(2-piperazin-1-yl-pyrimidin-5-yl)-biphenyl-2-yl]-pyrimidine-2,4-diamine TFA salt
InChi Key: FRBABIFCTILEGV-UHFFFAOYSA-N
InChi Code: InChI=1S/C31H30N8/c32-30-34-14-13-29(37-30)39(22-23-7-2-1-3-8-23)28-12-5-4-11-27(28)25-10-6-9-24(19-25)26-20-35-31(36-21-26)38-17-15-33-16-18-38/h1-14,19-21,33H,15-18,22H2,(H2,32,34,37)
SMILES Code: NC1=NC(N(CC2=CC=CC=C2)C3=CC=CC=C3C4=CC(C5=CN=C(N6CCNCC6)N=C5)=CC=C4)=CC=N1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 514.637 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|