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MedKoo CAT#: 407488

CAS#: 1370510-16-9

Description: Langkamide is a HIF-2 inhibitor, which showed HIF-2 inhibitory activity with EC₅₀ values of 14.0 uM. Langkamide may be used fortargeting HIFs mediated regulation of CSCs.

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-08-15. Prices are subject to change without notice.

Langkamide is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 407488
Name: Langkamide
CAS#: 1370510-16-9
Chemical Formula: C16H17NO5
Exact Mass: 303.1107
Molecular Weight: 303.314
Elemental Analysis: C, 63.36; H, 5.65; N, 4.62; O, 26.37

Synonym: Langkamide

IUPAC/Chemical Name: (Z)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-1,5-dihydro-2H-pyrrol-2-one


InChi Code: InChI=1S/C16H17NO5/c1-20-12-9-11(10-13(21-2)16(12)22-3)6-7-15(19)17-8-4-5-14(17)18/h4-7,9-10H,8H2,1-3H3/b7-6-

SMILES Code: O=C1N(C(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)=O)CC=C1

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Bokesch HR, Gardella RS, Rabe DC, Bottaro DP, Linehan WM, McMahon JB, McKee
TC. A new hypoxia inducible factor-2 inhibitory pyrrolinone alkaloid from roots
and stems of Piper sarmentosum. Chem Pharm Bull (Tokyo). 2011;59(9):1178-9.
PubMed PMID: 21881266; PubMed Central PMCID: PMC3166232.