WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532796

CAS#: 1196994-11-2 (free base)

Description: ST-1006 is a histamine H4 receptor agonist (H4R agonist). ST-1006 alleviates neuropathic pain through differential regulation of ERK, JNK, and P38 MAPK phosphorylation. During in vitro differentiation from monocytes to macrophages, the H4R agonist ST-1006 modified the M1 phenotype by up-regulating the macrophage differentiation marker CD68, by down-regulating the production of CXCL10, and by changing the morphology. In fully differentiated M1 macrophages, histamine or ST-1006 decreased the IFN-Ƴ- and LPS-induced CCL4 mRNA expression and protein production, whereas CCL3 or IL-23 production was not regulated via H4R.

Chemical Structure

CAS# 1196994-11-2 (free base)

Theoretical Analysis

MedKoo Cat#: 532796
Name: ST-1006
CAS#: 1196994-11-2 (free base)
Chemical Formula: C16H20Cl2N6
Exact Mass: 366.11
Molecular Weight: 367.280
Elemental Analysis: C, 52.32; H, 5.49; Cl, 19.30; N, 22.88

Price and Availability

Size Price Availability Quantity
50mg USD 550 2 Weeks
100mg USD 950 2 Weeks
200mg USD 1650 2 Weeks
500mg USD 2950 2 Weeks
1g USD 4250 2 Weeks
2g USD 6750 2 Weeks
Bulk inquiry

Related CAS #: 1196994-12-3 (maleate), 1196994-11-2 (free base),

Synonym: ST-1006; ST 1006; ST1006;

IUPAC/Chemical Name: 4-N-[(2,6-dichlorophenyl)methyl]-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine


InChi Code: InChI=1S/C16H20Cl2N6/c1-23-5-7-24(8-6-23)15-9-14(21-16(19)22-15)20-10-11-12(17)3-2-4-13(11)18/h2-4,9H,5-8,10H2,1H3,(H3,19,20,21,22)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Preparing Stock Solutions

The following data is based on the product molecular weight 367.280000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Beyer L, Kabatas AS, Mommert S, Stark H, Werfel T, Gutzmer R, Schaper- Gerhardt K. Histamine Activates Human Eosinophils via H2R and H4R Predominantly in Atopic Dermatitis Patients. Int J Mol Sci. 2022 Sep 7;23(18):10294. doi: 10.3390/ijms231810294. PMID: 36142206; PMCID: PMC9499661. 2: Ehling S, Butler A, Thi S, Ghashghaei HT, Bäumer W. To scratch an itch: Establishing a mouse model to determine active brain areas involved in acute histaminergic itch. IBRO Rep. 2018 Oct 15;5:67-73. doi: 10.1016/j.ibror.2018.10.002. PMID: 30364768; PMCID: PMC6197726. 3: Adami M, Micheloni C, Grandi D, Stark H. Differential effects of functionally different histamine H4 receptor ligands on acute irritant dermatitis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec;391(12):1387-1397. doi: 10.1007/s00210-018-1553-x. Epub 2018 Aug 25. PMID: 30145688. 4: Mommert S, Aslan D, Ratz L, Stark H, Gutzmer R, Werfel T. The Anaphylatoxin C3a Receptor Expression on Human M2 Macrophages Is Down-Regulated by Stimulating the Histamine H4 Receptor and the IL-4 Receptor. J Innate Immun. 2018;10(4):349-362. doi: 10.1159/000490426. Epub 2018 Jul 20. PMID: 30032131; PMCID: PMC6757164. 5: Mommert S, Ratz L, Stark H, Gutzmer R, Werfel T. The histamine H4 receptor modulates the differentiation process of human monocyte-derived M1 macrophages and the release of CCL4/MIP-1β from fully differentiated M1 macrophages. Inflamm Res. 2018 Jun;67(6):503-513. doi: 10.1007/s00011-018-1140-0. Epub 2018 Mar 29. PMID: 29600327. 6: Sanna MD, Mello T, Masini E, Galeotti N. Activation of ERK/CREB pathway in noradrenergic neurons contributes to hypernociceptive phenotype in H4 receptor knockout mice after nerve injury. Neuropharmacology. 2018 Jan;128:340-350. doi: 10.1016/j.neuropharm.2017.10.025. Epub 2017 Oct 28. PMID: 29107625. 7: Lucarini L, Pini A, Rosa AC, Lanzi C, Durante M, Chazot PL, Krief S, Schreeb A, Stark H, Masini E. Role of histamine H4 receptor ligands in bleomycin-induced pulmonary fibrosis. Pharmacol Res. 2016 Sep;111:740-748. doi: 10.1016/j.phrs.2016.07.037. Epub 2016 Jul 27. PMID: 27475884. 8: Ehling S, Roßbach K, Dunston SM, Stark H, Bäumer W. Allergic inflammation is augmented via histamine H4 receptor activation: The role of natural killer cells in vitro and in vivo. J Dermatol Sci. 2016 Aug;83(2):106-15. doi: 10.1016/j.jdermsci.2016.04.011. Epub 2016 Apr 22. PMID: 27155791. 9: Mommert S, Kleiner S, Gehring M, Eiz-Vesper B, Stark H, Gutzmer R, Werfel T, Raap U. Human basophil chemotaxis and activation are regulated via the histamine H4 receptor. Allergy. 2016 Sep;71(9):1264-73. doi: 10.1111/all.12875. Epub 2016 May 17. PMID: 26948974. 10: Sanna MD, Stark H, Lucarini L, Ghelardini C, Masini E, Galeotti N. Histamine H4 receptor activation alleviates neuropathic pain through differential regulation of ERK, JNK, and P38 MAPK phosphorylation. Pain. 2015 Dec;156(12):2492-2504. doi: 10.1097/j.pain.0000000000000319. PMID: 26270581. 11: Gschwandtner M, Koether B, Werfel T, Stark H, Gutzmer R. Profiling of histamine H4 receptor agonists in native human monocytes. Br J Pharmacol. 2013 Sep;170(1):136-43. doi: 10.1111/bph.12237. PMID: 23638754; PMCID: PMC3764855. 12: Stegaev V, Sillat T, Porola P, Hänninen A, Falus A, Mieliauskaite D, Buzás E, Rotar Z, Mackiewicz Z, Stark H, Chazot PL, Konttinen YT. Brief report: first identification of H₄ histamine receptor in healthy salivary glands and in focal sialadenitis in Sjögren's syndrome. Arthritis Rheum. 2012 Aug;64(8):2663-8. doi: 10.1002/art.34484. PMID: 22488408.