WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 525300
CAS#: 158985-00-3
Description: L-745870 is a highly potent and selective dopamine D4 receptor anatagonist.
MedKoo Cat#: 525300
Name: L-745870
CAS#: 158985-00-3
Chemical Formula: C18H19ClN4
Exact Mass: 326.1298
Molecular Weight: 326.828
Elemental Analysis: C, 66.15; H, 5.86; Cl, 10.85; N, 17.14
Synonym: L-745870
IUPAC/Chemical Name: 3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine
InChi Key: OGJGQVFWEPNYSB-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H19ClN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21)
SMILES Code: 3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine
1: Koga K, Nagai Y, Hanyu M, Yoshinaga M, Chaki S, Ohtake N, Ozaki S, Zhang MR, Suhara T, Higuchi M. High-contrast PET imaging of vasopressin V(1B) receptors with a novel radioligand, (11)C-TASP699. J Nucl Med. 2017 Apr 27. pii: jnumed.116.188698. doi: 10.2967/jnumed.116.188698. [Epub ahead of print] PubMed PMID: 28450560.
2: Iijima M, Yoshimizu T, Shimazaki T, Tokugawa K, Fukumoto K, Kurosu S, Kuwada T, Sekiguchi Y, Chaki S. Antidepressant and anxiolytic profiles of newly synthesized arginine vasopressin V1B receptor antagonists: TASP0233278 and TASP0390325. Br J Pharmacol. 2014 Jul;171(14):3511-25. doi: 10.1111/bph.12699. PubMed PMID: 24654684; PubMed Central PMCID: PMC4105937.