MKC-3946
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532773

CAS#: 1093119-54-0

Description: MKC3946 is a potent and soluble IRE1α inhibitor. MKC-3946 blocks XBP1 mRNA splicing and exhibits cytotoxicity against AML cells.


Chemical Structure

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MKC-3946
CAS# 1093119-54-0

Theoretical Analysis

MedKoo Cat#: 532773
Name: MKC-3946
CAS#: 1093119-54-0
Chemical Formula: C21H20N2O3S
Exact Mass: 380.1195
Molecular Weight: 380.46
Elemental Analysis: C, 66.30; H, 5.30; N, 7.36; O, 12.62; S, 8.43

Price and Availability

Size Price Availability Quantity
10.0mg USD 250.0 2 Weeks
25.0mg USD 450.0 2 Weeks
50.0mg USD 850.0 2 Weeks
100.0mg USD 1450.0 2 Weeks
Bulk inquiry

Synonym: MKC-3946; MKC 3946; MKC3946.

IUPAC/Chemical Name: 2-hydroxy-6-(5-(4-methylpiperazine-1-carbonyl)thiophen-2-yl)-1-naphthaldehyde

InChi Key: IVQVBMWPWPTSNO-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H20N2O3S/c1-22-8-10-23(11-9-22)21(26)20-7-6-19(27-20)15-2-4-16-14(12-15)3-5-18(25)17(16)13-24/h2-7,12-13,25H,8-11H2,1H3

SMILES Code: O=CC1=C(C=CC2=C1C=CC(C3=CC=C(S3)C(N4CCN(CC4)C)=O)=C2)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.0 52.57

Preparing Stock Solutions

The following data is based on the product molecular weight 380.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Mimura N, et al. Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma. Blood. 2012 Jun 14;119(24):5772-81.

2. Sun H, et al. Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia. Oncotarget. 2016 Apr 5;7(14):18736-49.

MKC-3946

10.0mg / USD 250.0