BTdCPU
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MedKoo CAT#: 407483

CAS#: 1257423-87-2

Description: BTdCPU is an activator of HRI. The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma. Combination therapy with rapamycin, an mTOR inhibitor, and BTdCPU, an activator of HRI, demonstrated additive effects on apoptosis in dex-resistant cells. Thus, specific activation of the eIF2α kinase HRI is a novel therapeutic target in MM that can augment current treatment strategies.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-03-30. Prices are subject to change without notice.

BTdCPU is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407483
Name: BTdCPU
CAS#: 1257423-87-2
Chemical Formula: C13H8Cl2N4OS
Exact Mass: 337.9796
Molecular Weight: 339.194
Elemental Analysis: C, 46.03; H, 2.38; Cl, 20.90; N, 16.52; O, 4.72; S, 9.45


Synonym: BTdCPU

IUPAC/Chemical Name: 1-(Benzo[d][1,2,3]thiadiazol-6-yl)-3-(3,4-dichlorophenyl)urea

InChi Key: NUUSUAWULNXMGF-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H8Cl2N4OS/c14-9-3-1-7(5-10(9)15)16-13(20)17-8-2-4-11-12(6-8)21-19-18-11/h1-6H,(H2,16,17,20)

SMILES Code: O=C(NC1=CC=C(Cl)C(Cl)=C1)NC2=CC=C3N=NSC3=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Burwick N, Zhang MY, de la Puente P, Azab AK, Hyun TS, Ruiz-Gutierrez M,
Sanchez-Bonilla M, Nakamura T, Delrow JJ, MacKay VL, Shimamura A. The eIF2-alpha
kinase HRI is a novel therapeutic target in multiple myeloma. Leuk Res. 2017
Apr;55:23-32. doi: 10.1016/j.leukres.2017.01.007. Epub 2017 Jan 12. PubMed PMID:
28119225; PubMed Central PMCID: PMC5354961.