G-36
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407479

CAS#: 1392487-51-2

Description: G-36, also known as GRB-G36, is a cell-permeable non-steroidal antagonist of GPER.


Chemical Structure

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G-36
CAS# 1392487-51-2

Theoretical Analysis

MedKoo Cat#: 407479
Name: G-36
CAS#: 1392487-51-2
Chemical Formula: C22H22BrNO2
Exact Mass: 411.0834
Molecular Weight: 412.327
Elemental Analysis: C, 64.09; H, 5.38; Br, 19.38; N, 3.40; O, 7.76

Price and Availability

Size Price Availability Quantity
1.0mg USD 175.0 2 Weeks
5.0mg USD 350.0 2 Weeks
10.0mg USD 600.0 2 Weeks
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Synonym: GRB-G36; G-36; G36; G 36.

IUPAC/Chemical Name: (4S)-rel-4-(6-bromo-1,3-benzodioxol-5-yl)-3aR,4,5,9bS-tetrahydro-8-(1-methylethyl)-3H-cyclopenta[c]quinoline

InChi Key: QTOCPACSSHFGOY-KIMHZCHSSA-N

InChi Code: InChI=1S/C22H22BrNO2/c1-12(2)13-6-7-19-16(8-13)14-4-3-5-15(14)22(24-19)17-9-20-21(10-18(17)23)26-11-25-20/h3-4,6-10,12,14-15,22,24H,5,11H2,1-2H3/t14-,15+,22-/m0/s1

SMILES Code: CC(C1=CC2=C(N[C@H](C3=C(Br)C=C(OCO4)C4=C3)[C@@]5([H])[C@]2([H])C=CC5)C=C1)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 412.327 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Alvarez P, Bogen O, Levine JD. Role of nociceptor estrogen receptor GPR30 in a rat model of endometriosis pain. Pain. 2014 Dec;155(12):2680-6. doi: 10.1016/j.pain.2014.09.035. Epub 2014 Oct 2. PubMed PMID: 25280432; PubMed Central PMCID: PMC4250399.

2: Ren Y, D'Ambrosio MA, Garvin JL, Leung P, Kutskill K, Wang H, Peterson EL, Carretero OA. Aldosterone sensitizes connecting tubule glomerular feedback via the aldosterone receptor GPR30. Am J Physiol Renal Physiol. 2014 Aug 15;307(4):F427-34. doi: 10.1152/ajprenal.00072.2014. Epub 2014 Jun 25. PubMed PMID: 24966088; PubMed Central PMCID: PMC4137129.

3: Oliveira JB, Vagnini LD, Petersen CG, Renzi A, Oliveira-Pelegrin GR, Mauri AL, Ricci J, Massaro FC, Dieamant F, Cavagna M, Baruffi RL, Franco JG Jr. Association between leukaemia inhibitory factor gene polymorphism and pregnancy outcomes after assisted reproduction techniques. Reprod Biomed Online. 2016 Jan;32(1):66-78. doi: 10.1016/j.rbmo.2015.09.018. Epub 2015 Oct 23. PubMed PMID: 26615902.

4: Sekiya S, Nishikawa F, Fukuda K, Nishikawa S. Structure/function analysis of an RNA aptamer for hepatitis C virus NS3 protease. J Biochem. 2003 Mar;133(3):351-9. PubMed PMID: 12761171.

5: Altmann JB, Yan G, Meeks JF, Abood ME, Brailoiu E, Brailoiu GC. G protein-coupled estrogen receptor-mediated effects on cytosolic calcium and nanomechanics in brain microvascular endothelial cells. J Neurochem. 2015 Jun;133(5):629-39. doi: 10.1111/jnc.13066. Epub 2015 Mar 2. PubMed PMID: 25703621; PubMed Central PMCID: PMC4562690.

6: Gomes LM, Canha Ados S, Dzik A, Novo NF, Juliano Y, Dos Santos SI, Cavagna M. [The age as a predictive factor in in vitro fertilization cycles]. Rev Bras Ginecol Obstet. 2009 May;31(5):230-4. Portuguese. PubMed PMID: 19669030.

7: Brailoiu GC, Benamar K, Arterburn JB, Gao E, Rabinowitz JE, Koch WJ, Brailoiu E. Aldosterone increases cardiac vagal tone via G protein-coupled oestrogen receptor activation. J Physiol. 2013 Sep 1;591(17):4223-35. doi: 10.1113/jphysiol.2013.257204. Epub 2013 Jul 22. PubMed PMID: 23878371; PubMed Central PMCID: PMC3779113.

8: Senent ML, Dominguez-Gomez R, Carvajal M, Villa M. CCSD(T) study of CD3-O-CD3 and CH3-O-CD3 far-infrared spectra. J Phys Chem A. 2012 Jun 28;116(25):6901-10. doi: 10.1021/jp3030107. Epub 2012 Jun 8. PubMed PMID: 22642772.

9: Yau AM, McLaughlin J, Gilmore W, Maughan RJ, Evans GH. The Acute Effects of Simple Sugar Ingestion on Appetite, Gut-Derived Hormone Response, and Metabolic Markers in Men. Nutrients. 2017 Feb 14;9(2). pii: E135. doi: 10.3390/nu9020135. PubMed PMID: 28216550; PubMed Central PMCID: PMC5331566.

10: Yang H, Embry RE, Main RP. Effects of Loading Duration and Short Rest Insertion on Cancellous and Cortical Bone Adaptation in the Mouse Tibia. PLoS One. 2017 Jan 11;12(1):e0169519. doi: 10.1371/journal.pone.0169519. eCollection 2017. PubMed PMID: 28076363; PubMed Central PMCID: PMC5226737.

11: Toyonaga T, Man-i M, Chinzei R, Takada N, Iwata Y, Morita Y, Sanuki T, Yoshida M, Fujita T, Kutsumi H, Hayakumo T, Inokuchi H, Azuma T. Endoscopic treatment for early stage colorectal tumors: the comparison between EMR with small incision, simplified ESD, and ESD using the standard flush knife and the ball tipped flush knife. Acta Chir Iugosl. 2010;57(3):41-6. PubMed PMID: 21066982.

12: Sutherland K, Takaya H, Qian J, Petocz P, Ng AT, Cistulli PA. Oral Appliance Treatment Response and Polysomnographic Phenotypes of Obstructive Sleep Apnea. J Clin Sleep Med. 2015 Aug 15;11(8):861-8. doi: 10.5664/jcsm.4934. PubMed PMID: 25845897; PubMed Central PMCID: PMC4513263.

13: Zhang J, Shih T, Lu Y, Merlitz H, Chang RR, Chen Z. Non-synchronization of lattice and carrier temperatures in light-emitting diodes. Sci Rep. 2016 Jan 20;6:19539. doi: 10.1038/srep19539. PubMed PMID: 26785685; PubMed Central PMCID: PMC4726174.

14: Choi HW, Navia JA, Kassab GS. Thrombus deflector stent for stroke prevention: A simulation study. J Biomech. 2015 Jul 16;48(10):1789-95. doi: 10.1016/j.jbiomech.2015.05.006. Epub 2015 May 22. PubMed PMID: 26049978.

15: Giese A, Uyar M, Henning BF, Uslucan HH, Westhoff T, Pagonas N. [How do Turkish immigrants evaluate cultural sensitivity in a German tertiary hospital?]. Dtsch Med Wochenschr. 2015 Jan;140(2):e14-20. doi: 10.1055/s-0041-100007. Epub 2015 Jan 22. German. PubMed PMID: 25612288.

16: Manzoni P, Wu C, Tweddle L, Roilides E. Micafungin in premature and non-premature infants: a systematic review of 9 clinical trials. Pediatr Infect Dis J. 2014 Nov;33(11):e291-8. doi: 10.1097/INF.0000000000000434. Review. PubMed PMID: 24892849; PubMed Central PMCID: PMC4196786.

17: Brovarets' OO, Hovorun DM. How does the long G•G* Watson-Crick DNA base mispair comprising keto and enol tautomers of the guanine tautomerise? The results of a QM/QTAIM investigation. Phys Chem Chem Phys. 2014 Aug 14;16(30):15886-99. doi: 10.1039/c4cp01241k. PubMed PMID: 24964351.

18: Steinhauser G. Fukushima's forgotten radionuclides: a review of the understudied radioactive emissions. Environ Sci Technol. 2014 May 6;48(9):4649-63. doi: 10.1021/es405654c. Epub 2014 Apr 23. Review. PubMed PMID: 24754713.

19: Raman SR, Landry MD, Ottensmeyer CA, Jacob S, Hamdan E, Bouhaimed M. Keeping our children safe in motor vehicles: knowledge, attitudes and practice among parents in Kuwait regarding child car safety. Int J Inj Contr Saf Promot. 2013;20(4):358-67. doi: 10.1080/17457300.2012.745578. Epub 2012 Dec 12. PubMed PMID: 23230995.

20: Aikawa H, Noro M. Low incidence of sight-threatening retinopathy of prematurity in infants born before 28 weeks gestation at a neonatal intensive care unit in Japan. Tohoku J Exp Med. 2013;230(3):185-90. PubMed PMID: 23883589.

G-36

1.0mg / USD 175.0