A-834735

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530626

CAS#: 895155-57-4

Description: A-834735 is a drug developed by Abbott Laboratories that acts as a potent cannabinoid receptor full agonist at both the CB1 and CB2 receptors, with a Ki of 12 nM at CB1 and 0.21 nM at CB2.


Chemical Structure

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A-834735
CAS# 895155-57-4

Theoretical Analysis

MedKoo Cat#: 530626
Name: A-834735
CAS#: 895155-57-4
Chemical Formula: C22H29NO2
Exact Mass: 339.2198
Molecular Weight: 339.479
Elemental Analysis: C, 77.84; H, 8.61; N, 4.13; O, 9.43

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: A-834735; A 834735; A834735; A-834,735; A 834,735; A834,735.

IUPAC/Chemical Name: [1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)-methanone

InChi Key: NQTMRZNYLIGQCF-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H29NO2/c1-21(2)20(22(21,3)4)19(24)17-14-23(13-15-9-11-25-12-10-15)18-8-6-5-7-16(17)18/h5-8,14-15,20H,9-13H2,1-4H3

SMILES Code: O=C(C1=CN(CC2CCOCC2)C3=C1C=CC=C3)C4C(C)(C)C4(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 339.479 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Byrska B, Stanaszek R, Zuba D. Alpha-PVP as an active component of herbal
highs in Poland between 2013 and 2015. Drug Test Anal. 2016 Dec 30. doi:
10.1002/dta.2151. [Epub ahead of print] PubMed PMID: 28035764.

2: Grim TW, Morales AJ, Gonek MM, Wiley JL, Thomas BF, Endres GW, Sim-Selley LJ,
Selley DE, Negus SS, Lichtman AH. Stratification of Cannabinoid 1 Receptor (CB1R)
Agonist Efficacy: Manipulation of CB1R Density through Use of Transgenic Mice
Reveals Congruence between In Vivo and In Vitro Assays. J Pharmacol Exp Ther.
2016 Nov;359(2):329-339. Epub 2016 Aug 17. PubMed PMID: 27535976; PubMed Central
PMCID: PMC5074482.