WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 530618
Description: BCM-599 is a HBV capsid assembly inhibitor. BCM-599 could be utilized as an effective combination treatment against HBV infection. BCM-599 showed IC50 of 0.88 μM and CC50 of 144 μM in HepG2.2.15 cells. BCM-599 decreased both intracellular and extracellular viral DNA levels without affecting the pgRNA level; moreover, interestingly, at the concentration of 0.88 μM, BCM-599 reduced the intracellular capsid level by 51% while increased the amount of free core protein dimer by 5-fold.
MedKoo Cat#: 530618
Chemical Formula: C14H10Cl2FN3O2
Exact Mass: 341.0134
Molecular Weight: 342.1514
Elemental Analysis: C, 49.15; H, 2.95; Cl, 20.72; F, 5.55; N, 12.28; O, 9.35
Synonym: BCM-599; BCM 599; BCM599.
IUPAC/Chemical Name: N-(2-((2,6-dichloropyridin-3-yl)amino)-2-oxoethyl)-4-fluorobenzamide
InChi Key: HGXMWUZBYQFEPM-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H10Cl2FN3O2/c15-11-6-5-10(13(16)20-11)19-12(21)7-18-14(22)8-1-3-9(17)4-2-8/h1-6H,7H2,(H,18,22)(H,19,21)
SMILES Code: FC1=CC=C(C(NCC(NC2=C(Cl)N=C(Cl)C=C2)=O)=O)C=C1
1: Cho MH, Jeong H, Kim YS, Kim JW, Jung G.
2-amino-N-(2,6-dichloropyridin-3-yl)acetamide derivatives as a novel class of HBV
capsid assembly inhibitor. J Viral Hepat. 2014 Dec;21(12):843-52. doi:
10.1111/jvh.12214. Epub 2013 Dec 25. PubMed PMID: 24372792.