Ro0711401
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532549

CAS#: 714971-87-6

Description: Ro0711401 is a mGlu1 receptor agonist.

Chemical Structure

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Ro0711401
CAS# 714971-87-6
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 532549
Name: Ro0711401
CAS#: 714971-87-6
Chemical Formula: C18H11F3N2O3
Exact Mass: 360.07
Molecular Weight: 360.290
Elemental Analysis: C, 60.01; H, 3.08; F, 15.82; N, 7.78; O, 13.32

Price and Availability

Size Price Availability Quantity
10mg USD 90 Ready to ship
25mg USD 190 Ready to ship
50mg USD 350 Ready to ship
100mg USD 550 Ready to ship
200mg USD 950 Ready to ship
500mg USD 1950 Ready to ship
1g USD 3450 Ready to ship
2g USD 6150 Ready to ship
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Synonym: Ro0711401; Ro-0711401; Ro 0711401.

IUPAC/Chemical Name: N-[4-(trifluoromethyl)-1,3-oxazol-2-yl]-9H-xanthene-9-carboxamide

InChi Key: GSGDLBUOSWGZER-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H11F3N2O3/c19-18(20,21)14-9-25-17(22-14)23-16(24)15-10-5-1-3-7-12(10)26-13-8-4-2-6-11(13)15/h1-9,15H,(H,22,23,24)

SMILES Code: O=C(C1C2=C(OC3=C1C=CC=C3)C=CC=C2)NC4=NC(C(F)(F)F)=CO4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: RO0711401 is a selective and orally active positive allosteric modulator of mGlu1 receptor with an EC50 of 56 nM.
In vitro activity: To be determined
In vivo activity: mGlu5 receptor PAMs are potential candidates for the treatment of absence epilepsy in humans. Treatment with RO0711401 enhanced the expression of both mGlu1a and mGlu5 receptors in the thalamus and cortex of WAG/Rij rats. However, in non-epileptic rats, repeated injections of RO0711401 and VU0360172 down-regulated the expression of mGlu1a and mGlu5 receptors. Levels of RO0711401 were reduced in the cortex at day 8 of treatment. Reference: Neuropharmacology. 2014 Oct;85:91-103. https://pubmed.ncbi.nlm.nih.gov/24859611/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100.0 277.55

Preparing Stock Solutions

The following data is based on the product molecular weight 360.290000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Liberatore F, Antenucci N, Tortolani D, Mascio G, Fanti F, Sergi M, Battaglia G, Bruno V, Nicoletti F, Maccarrone M, Notartomaso S. Targeting mGlu1 Receptors in the Treatment of Motor and Cognitive Dysfunctions in Mice Modeling Type 1 Spinocerebellar Ataxia. Cells. 2022 Dec 3;11(23):3916. doi: 10.3390/cells11233916. PMID: 36497172; PMCID: PMC9738505. 2. D'Amore V, Santolini I, Celli R, Lionetto L, De Fusco A, Simmaco M, van Rijn CM, Vieira E, Stauffer SR, Conn PJ, Bosco P, Nicoletti F, van Luijtelaar G, Ngomba RT. Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology. 2014 Oct;85:91-103. doi: 10.1016/j.neuropharm.2014.05.005. Epub 2014 May 20. PMID: 24859611; PMCID: PMC4356528.
In vitro protocol: To be determined
In vivo protocol: 1. Liberatore F, Antenucci N, Tortolani D, Mascio G, Fanti F, Sergi M, Battaglia G, Bruno V, Nicoletti F, Maccarrone M, Notartomaso S. Targeting mGlu1 Receptors in the Treatment of Motor and Cognitive Dysfunctions in Mice Modeling Type 1 Spinocerebellar Ataxia. Cells. 2022 Dec 3;11(23):3916. doi: 10.3390/cells11233916. PMID: 36497172; PMCID: PMC9738505. 2. D'Amore V, Santolini I, Celli R, Lionetto L, De Fusco A, Simmaco M, van Rijn CM, Vieira E, Stauffer SR, Conn PJ, Bosco P, Nicoletti F, van Luijtelaar G, Ngomba RT. Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology. 2014 Oct;85:91-103. doi: 10.1016/j.neuropharm.2014.05.005. Epub 2014 May 20. PMID: 24859611; PMCID: PMC4356528.

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1: D'Amore V, Santolini I, Celli R, Lionetto L, De Fusco A, Simmaco M, van Rijn CM, Vieira E, Stauffer SR, Conn PJ, Bosco P, Nicoletti F, van Luijtelaar G, Ngomba RT. Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology. 2014 Oct;85:91-103. doi: 10.1016/j.neuropharm.2014.05.005. Epub 2014 May 20. PubMed PMID: 24859611; PubMed Central PMCID: PMC4356528.