WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530604

CAS#: 17318-31-9

Description: SQ-22536, also known as NSC 53339, is an inhibitor of adenylyl cyclase with an IC50 value of 13 μM. SQ 22536 prevents the antiplatelet effect of dazoxiben, a thromboxane-synthetase inhibitor. SQ 22536 inhibited adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC] activity of crude membrane preparations from catfish (Ictalurus melas) and rat isolated hepatocytes in a non-competitive manner.

Price and Availability


USD 750
USD 2950

USD 1250
USD 3950

USD 1950
USD 5950

SQ-22536, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 530604
Name: SQ-22536
CAS#: 17318-31-9
Chemical Formula: C9H11N5O
Exact Mass: 205.0964
Molecular Weight: 205.221
Elemental Analysis: C, 52.67; H, 5.40; N, 34.13; O, 7.80

Synonym: SQ-22536; SQ22536; SQ 22536; SQ-22,536; SQ22,536; SQ 22,536. NSC 53339.

IUPAC/Chemical Name: 9-(tetrahydro-2-furanyl)-9H-purin-6-amine


InChi Code: InChI=1S/C9H11N5O/c10-8-7-9(12-4-11-8)14(5-13-7)6-2-1-3-15-6/h4-6H,1-3H2,(H2,10,11,12)


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


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2: Gao Y, Usha Raj J. Effects of SQ 22536, an adenylyl cyclase inhibitor, on isoproterenol-induced cyclic AMP elevation and relaxation in newborn ovine pulmonary veins. Eur J Pharmacol. 2002 Feb 2;436(3):227-33. PubMed PMID: 11858802.

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16: Kim HW, Li H, Kim HS, Shin SE, Jung WK, Ha KS, Han ET, Hong SH, Choi IW, Firth AL, Bang H, Park WS. The anti-diabetic drug repaglinide induces vasorelaxation via activation of PKA and PKG in aortic smooth muscle. Vascul Pharmacol. 2016 Sep;84:38-46. doi: 10.1016/j.vph.2016.07.005. Epub 2016 Jul 18. PubMed PMID: 27435474.

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