Acepromazine maleate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 540001

CAS#: 3598-37-6 (maleate)

Description: Acepromazine maleate, also known as Sch-10649, is a dopamine D1/2 receptor and 5-HT1A/2A receptor antagonist used to prevent nausea and induce sedation.

Chemical Structure

Acepromazine maleate
CAS# 3598-37-6 (maleate)

Theoretical Analysis

MedKoo Cat#: 540001
Name: Acepromazine maleate
CAS#: 3598-37-6 (maleate)
Chemical Formula: C23H26N2O5S
Exact Mass: 442.1562
Molecular Weight: 442.53
Elemental Analysis: C, 62.43; H, 5.92; N, 6.33; O, 18.08; S, 7.24

Price and Availability

Size Price Availability Quantity
5.0g USD 450.0 2 Weeks
10.0g USD 750.0 2 Weeks
25.0g USD 1450.0 2 Weeks
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Related CAS #: 3598-37-6 (maleate)   61-00-7 (free base)    

Synonym: Acepromazine maleate; Acepromazine; Sch-10649; Sch 10649; Sch10649

IUPAC/Chemical Name: 1-(10-(3-(dimethylamino)propyl)-10H-phenothiazin-2-yl)ethan-1-one maleate


InChi Code: InChI=1S/C19H22N2OS.C4H4O4/c1-14(22)15-9-10-19-17(13-15)21(12-6-11-20(2)3)16-7-4-5-8-18(16)23-19;5-3(6)1-2-4(7)8/h4-5,7-10,13H,6,11-12H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 442.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Koh RB, Isaza N, Xie H, Cooke K, Robertson SA. Effects of maropitant, acepromazine, and electroacupuncture on vomiting associated with administration of morphine in dogs. J Am Vet Med Assoc. 2014 Apr 1;244(7):820-9. doi: 10.2460/javma.244.7.820. PubMed PMID: 24649993.

2: Schneiders FI, Noble GK, Boston RC, Dunstan AJ, Sillence MN, McKinney AR. Acepromazine pharmacokinetics: a forensic perspective. Vet J. 2012 Oct;194(1):48-54. doi: 10.1016/j.tvjl.2012.03.017. Epub 2012 Apr 23. PubMed PMID: 22534188.

3: Conner BJ, Hanel RM, Hansen BD, Motsinger-Reif AA, Asakawa M, Swanson CR. Effects of acepromazine maleate on platelet function assessed by use of adenosine diphosphate activated- and arachidonic acid- activated modified thromboelastography in healthy dogs. Am J Vet Res. 2012 May;73(5):595-601. doi: 10.2460/ajvr.73.5.595. PubMed PMID: 22533389.

4: Henao-Guerrero N, Riccó CH. Comparison of the cardiorespiratory effects of a combination of ketamine and propofol, propofol alone, or a combination of ketamine and diazepam before and after induction of anesthesia in dogs sedated with acepromazine and oxymorphone. Am J Vet Res. 2014 Mar;75(3):231-9. doi: 10.2460/ajvr.75.3.231. PubMed PMID: 24564308.

5: Wolfe LL, Johnson HE, Fisher MC, Sirochman MA, Kraft B, Miller MW. Use of acepromazine and medetomidine in combination for sedation and handling of Rocky Mountain elk (Cervus elaphus nelsoni) and black bears (Ursus americanus). J Wildl Dis. 2014 Oct;50(4):979-81. doi: 10.7589/2014-02-052. Epub 2014 Jul 11. PubMed PMID: 25014907.

6: Mouney MC, Accola PJ, Cremer J, Shepard MK, Rodriguez Guarin C, Hofmeister EH. Effects of acepromazine maleate or morphine on tear production before, during, and after sevoflurane anesthesia in dogs. Am J Vet Res. 2011 Nov;72(11):1427-30. doi: 10.2460/ajvr.72.11.1427. PubMed PMID: 22023119.

7: Grasso SC, Ko JC, Weil AB, Paranjape V, Constable PD. Hemodynamic influence of acepromazine or dexmedetomidine premedication in isoflurane-anesthetized dogs. J Am Vet Med Assoc. 2015 Apr 1;246(7):754-64. doi: 10.2460/javma.246.7.754. PubMed PMID: 25794125.

8: Nogueira RB, Fernández del Palacio MJ, López JT, Resende RM. Effects of sedation with acepromazine maleate and buprenorphine hydrochloride on femoral artery blood flow in healthy dogs. Res Vet Sci. 2012 Oct;93(2):989-92. doi: 10.1016/j.rvsc.2011.10.004. Epub 2011 Nov 1. PubMed PMID: 22047817.

9: Kamali MF, Wilson AC, Acquisto NM, Spillane L, Schneider SM. Acute encephalopathy with concurrent respiratory and metabolic disturbances in first known parenteral human administration of flunixin meglumine and acepromazine maleate. J Emerg Med. 2013 Aug;45(2):206-9. doi: 10.1016/j.jemermed.2012.11.088. Epub 2013 Mar 20. PubMed PMID: 23522957.

10: Casas-Díaz E, Marco I, López-Olvera JR, Mentaberre G, Serrano E, Lavín S. Effect of acepromazine and haloperidol in male Iberian Ibex (Capra pyrenaica) captured by box-trap. J Wildl Dis. 2012 Jul;48(3):763-7. PubMed PMID: 22740543.

11: Schier MF, Raisis AL, Secombe CJ, Hosgood G, Musk GC, Lester GD. Effects of dobutamine hydrochloride on cardiovascular function in horses anesthetized with isoflurane with or without acepromazine maleate premedication. Am J Vet Res. 2016 Dec;77(12):1318-1324. PubMed PMID: 27901396.

12: Algren DA, Ashworth A. Acute acepromazine overdose: clinical effects and toxicokinetic evaluation. J Med Toxicol. 2015 Mar;11(1):121-3. doi: 10.1007/s13181-014-0416-1. PubMed PMID: 25059809; PubMed Central PMCID: PMC4371025.

13: Simon BT, Scallan EM, Siracusa C, Henderson A, Sleeper MM, Larenza Menzies MP. Effects of acepromazine or methadone on midazolam-induced behavioral reactions in dogs. Can Vet J. 2014 Sep;55(9):875-85. PubMed PMID: 25183896; PubMed Central PMCID: PMC4137930.

14: López-Sanromán FJ, Gómez Cisneros D, Varela del Arco M, Santiago Llorente I, Santos González M. The use of low doses of acepromazine as an aid for lameness diagnosis in horses: An accelerometric evaluation. Vet Comp Orthop Traumatol. 2015;28(5):312-7. doi: 10.3415/VCOT-14-11-0177. Epub 2015 Jul 29. PubMed PMID: 26219640.

15: Saponaro V, Crovace A, De Marzo L, Centonze P, Staffieri F. Echocardiographic evaluation of the cardiovascular effects of medetomidine, acepromazine and their combination in healthy dogs. Res Vet Sci. 2013 Oct;95(2):687-92. doi: 10.1016/j.rvsc.2013.03.022. Epub 2013 May 2. PubMed PMID: 23642485.

16: Zapata M, Hofmeister EH. Refinement of the dose of doxapram to counteract the sedative effects of acepromazine in dogs. J Small Anim Pract. 2013 Aug;54(8):405-8. doi: 10.1111/jsap.12105. PubMed PMID: 23879828.

17: Chu ER, Kim EK, Gonzalez JM Jr, Ko MH, Liew EC, Tan JC. Intraocular pressure measurement in acepromazine-sedated mice. Clin Exp Ophthalmol. 2014 May-Jun;42(4):395-7. doi: 10.1111/ceo.12157. Epub 2013 Jul 15. PubMed PMID: 23777364.

18: Monteiro ER, Nunes-Junior JS, Bressan TF. Randomized clinical trial of the effects of a combination of acepromazine with morphine and midazolam on sedation, cardiovascular variables and the propofol dose requirements for induction of anesthesia in dogs. Vet J. 2014 Apr;200(1):157-61. doi: 10.1016/j.tvjl.2014.01.018. Epub 2014 Feb 5. PubMed PMID: 24582061.

19: Bortolami E, Murrell JC, Slingsby LS. Methadone in combination with acepromazine as premedication prior to neutering in the cat. Vet Anaesth Analg. 2013 Mar;40(2):181-93. doi: 10.1111/j.1467-2995.2012.00736.x. Epub 2012 Jun 26. PubMed PMID: 22731882.

20: Hofmeister EH, Chandler MJ, Read MR. Effects of acepromazine, hydromorphone, or an acepromazine-hydromorphone combination on the degree of sedation in clinically normal dogs. J Am Vet Med Assoc. 2010 Nov 15;237(10):1155-9. doi: 10.2460/javma.237.10.1155. Erratum in: J Am Vet Med Assoc. 2011 jAN 15;238(2):182. Dosage error in published abstract; MEDLINE/PubMed abstract corrected. PubMed PMID: 21073386.