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MedKoo CAT#: 530585

CAS#: 1005459-82-4

Description: Z060228 is an potent anti-HBV inhibitor. The HBV DNA replication in the supernatants of the HepG2.2.15 cells was effectively inhibited by Z060228. Z060228 exhibited effects on the self-assembly of Cp149. SEC data revealed that Z060228 altered the equilibrium (a state of stability) of Cp149 assembly. Z060228 could prevent Cp149 from self-assembling to the correct core particles. Z060228 was demonstrated to be a potential capsid targeting anti-HBV drug candidate.

Price and Availability

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Pricing updated 2020-10-25. Prices are subject to change without notice.

Z060228 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 530585
Name: Z060228
CAS#: 1005459-82-4
Chemical Formula: C20H15ClF4N2O2
Exact Mass: 426.0758
Molecular Weight: 426.7956
Elemental Analysis: C, 56.28; H, 3.54; Cl, 8.31; F, 17.81; N, 6.56; O, 7.50

Synonym: Z060228; Z-060228; Z 060228.

IUPAC/Chemical Name: ethyl (R)-4-(2-chloro-4-fluorophenyl)-6-methyl-2-(2,4,6-trifluorophenyl)-1,4-dihydropyrimidine-5-carboxylate


InChi Code: InChI=1S/C20H15ClF4N2O2/c1-3-29-20(28)16-9(2)26-19(17-14(24)7-11(23)8-15(17)25)27-18(16)12-5-4-10(22)6-13(12)21/h4-8,18H,3H2,1-2H3,(H,26,27)/t18-/m0/s1

SMILES Code: CC1=C(C(OCC)=O)[C@H](C2=C(Cl)C=C(F)C=C2)N=C(C3=C(F)C=C(F)C=C3F)N1

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Guan H, Zhao G, Chen W, Wu G, Liu H, Jiang X, Li S, Wang LL. The novel
compound Z060228 inhibits assembly of the HBV capsid. Life Sci. 2015 Jul
15;133:1-7. doi: 10.1016/j.lfs.2015.04.011. Epub 2015 Apr 25. PubMed PMID: