CC-885
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MedKoo CAT#: 206829

CAS#: 1010100-07-8

Description: CC-885 is a potent Cereblon Modulator with potent antitumor activity mediated through the degradation of GSPT1. was demonstrated to mediate antitumor effects through the recruitment and degradation of G1 to S phase transition 1 protein (GSPT1). GSPT1 (also named eRF3a) is a translation termination factor that binds eukaryotic translation termination factor 1 (eFR1) to mediate stop codon recognition and nascent protein release from the ribosome.


Price and Availability

Size
Price

5mg
USD 110
50mg
USD 650
Size
Price

10mg
USD 190
100mg
USD 1050
Size
Price

25mg
USD 390
200mg
USD 1850

CC-885, purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 206829
Name: CC-885
CAS#: 1010100-07-8
Chemical Formula: C22H21ClN4O4
Exact Mass: 440.1251
Molecular Weight: 440.884
Elemental Analysis: C, 59.93; H, 4.80; Cl, 8.04; N, 12.71; O, 14.52


Synonym: CC-885, CC 885, CC885.

IUPAC/Chemical Name: N-(3-chloro-4-methylphenyl)-N'-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-urea

InChi Key: DOEVCIHTTTYVCC-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H21ClN4O4/c1-12-2-4-15(9-17(12)23)25-22(31)24-10-13-3-5-16-14(8-13)11-27(21(16)30)18-6-7-19(28)26-20(18)29/h2-5,8-9,18H,6-7,10-11H2,1H3,(H2,24,25,31)(H,26,28,29)

SMILES Code: O=C(NCC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2)=O)C=C1)NC4=CC=C(C)C(Cl)=C4


Technical Data

Appearance:
Off white to light purple solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


References

1: Matyskiela ME, Lu G, Ito T, Pagarigan B, Lu CC, Miller K, Fang W, Wang NY,
Nguyen D, Houston J, Carmel G, Tran T, Riley M, Nosaka L, Lander GC, Gaidarova S,
Xu S, Ruchelman AL, Handa H, Carmichael J, Daniel TO, Cathers BE, Lopez-Girona A,
Chamberlain PP. A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN)
ubiquitin ligase. Nature. 2016 Jul 14;535(7611):252-7. doi: 10.1038/nature18611.
Epub 2016 Jun 22. PubMed PMID: 27338790.

2: The Cereblon Modulator CC-885 Exhibits Antitumor Activity. Cancer Discov. 2016
Aug;6(8):OF15. doi: 10.1158/2159-8290.CD-RW2016-123. Epub 2016 Jul 1. PubMed
PMID: 27369046.

3: Hansen JD, Condroski K, Correa M, Muller G, Man HW, Ruchelman A, Zhang W,
Vocanson F, Crea T, Liu W, Lu G, Baculi F, LeBrun L, Mahmoudi A, Carmel G,
Hickman M, Lu CC. Protein Degradation via CRL4(CRBN) Ubiquitin Ligase: Discovery
and Structure-Activity Relationships of Novel Glutarimide Analogs That Promote
Degradation of Aiolos and/or GSPT1. J Med Chem. 2017 Apr 13. doi:
10.1021/acs.jmedchem.6b01911. [Epub ahead of print] PubMed PMID: 28358507.