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Iberdomide
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 528831

CAS#: 1323403-33-3

Description: Iberdomide, also known as CC-220, is potentially for the treatment of systemic lupus erythematosus. Iberdomide significantly reduced Ikaros and Aiolos protein levels in B cells, T cells and monocytes. In SLE PBMC cultures, iberdomide inhibited anti-dsDNA and anti-phospholipid autoantibody production (IC50 ≈10 nM).


Price and Availability

Size Price Shipping out time Quantity
5mg USD 260 2 Weeks
100mg USD 1150 2 Weeks
200mg USD 1650 2 Weeks
500mg USD 2650 2 Weeks
1g USD 3650 2 Weeks
2g USD 5650 2 Weeks
5g USD 11450 2 Weeks
Inquire bulk and customized quantity
Pricing updated 2020-10-28. Prices are subject to change without notice.

Iberdomide, purity > 98%, is in stock. Current shipping out time is about 2-3 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 528831
Name: Iberdomide
CAS#: 1323403-33-3
Chemical Formula: C25H27N3O5
Exact Mass: 449.1951
Molecular Weight: 449.5
Elemental Analysis: C, 66.80; H, 6.05; N, 9.35; O, 17.80


Synonym: CC-220; CC220; CC 220; Iberdomide.

IUPAC/Chemical Name: (S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

InChi Key: IXZOHGPZAQLIBH-NRFANRHFSA-N

InChi Code: InChI=1S/C25H27N3O5/c29-23-9-8-21(24(30)26-23)28-15-20-19(25(28)31)2-1-3-22(20)33-16-18-6-4-17(5-7-18)14-27-10-12-32-13-11-27/h1-7,21H,8-16H2,(H,26,29,30)/t21-/m0/s1

SMILES Code: O=C([C@@H](N(CC1=C2C=CC=C1OCC3=CC=C(CN4CCOCC4)C=C3)C2=O)CC5)NC5=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:
View CoA: previous batch, Lot#C8M03C05
View CoA: current batch, Lot#C9M04C30

Safety Data Sheet (SDS):
View Safety Data Sheet (SDS)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Skinner C, Gaddie J, Palmer KN. Comparison of intravenous AH 5158 (ibidomide)
and propranolol in asthma. Br Med J. 1975 Apr 12;2(5962):59-61. PubMed PMID:
236806; PubMed Central PMCID: PMC1673027.