WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 528831
CAS#: 1323403-33-3
Description: Iberdomide, also known as CC-220, is potentially for the treatment of systemic lupus erythematosus. Iberdomide significantly reduced Ikaros and Aiolos protein levels in B cells, T cells and monocytes. In SLE PBMC cultures, iberdomide inhibited anti-dsDNA and anti-phospholipid autoantibody production (IC50 ≈10 nM).
MedKoo Cat#: 528831
Name: Iberdomide
CAS#: 1323403-33-3
Chemical Formula: C25H27N3O5
Exact Mass: 449.1951
Molecular Weight: 449.5
Elemental Analysis: C, 66.80; H, 6.05; N, 9.35; O, 17.80
Synonym: CC-220; CC220; CC 220; Iberdomide.
IUPAC/Chemical Name: (S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
InChi Key: IXZOHGPZAQLIBH-NRFANRHFSA-N
InChi Code: InChI=1S/C25H27N3O5/c29-23-9-8-21(24(30)26-23)28-15-20-19(25(28)31)2-1-3-22(20)33-16-18-6-4-17(5-7-18)14-27-10-12-32-13-11-27/h1-7,21H,8-16H2,(H,26,29,30)/t21-/m0/s1
SMILES Code: O=C([C@@H](N(CC1=C2C=CC=C1OCC3=CC=C(CN4CCOCC4)C=C3)C2=O)CC5)NC5=O
1: Skinner C, Gaddie J, Palmer KN. Comparison of intravenous AH 5158 (ibidomide)
and propranolol in asthma. Br Med J. 1975 Apr 12;2(5962):59-61. PubMed PMID:
236806; PubMed Central PMCID: PMC1673027.
