WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 558216
CAS#: 189362-06-9
Description: K-134 is a PDE3 inhibitor potentially for the treatment of anti-thrombotic and anti-hyperplastic activities.
MedKoo Cat#: 558216
Name: K-134
CAS#: 189362-06-9
Chemical Formula: C22H29N3O4
Exact Mass:
Molecular Weight: 399.491
Elemental Analysis: C, 66.14; H, 7.32; N, 10.52; O, 16.02
This product is not in stock, which may be available by custom synthesis.
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Synonym: K-134; OPC-33509; K134; OPC33509; K 134; OPC 33509
IUPAC/Chemical Name: 1-cyclopropyl-1-((1R,2R)-2-hydroxycyclohexyl)-3-(3-((2-oxo-1,2-dihydroquinolin-6-yl)oxy)propyl)urea
InChi Key: ULGNGSQNNMKROG-WOJBJXKFSA-N
InChi Code: InChI=1S/C22H29N3O4/c26-20-5-2-1-4-19(20)25(16-7-8-16)22(28)23-12-3-13-29-17-9-10-18-15(14-17)6-11-21(27)24-18/h6,9-11,14,16,19-20,26H,1-5,7-8,12-13H2,(H,23,28)(H,24,27)/t19-,20-/m1/s1
SMILES Code: O=C(NCCCOC1=CC2=C(NC(C=C2)=O)C=C1)N(C3CC3)[C@H]4[C@H](O)CCCC4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 399.491 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Sasaki Y, Suzuki H, Itoh S, Yoshida H, Kondo S, Inoue K, Tanabe S. K-134, a phosphodiesterase 3 inhibitor, improves gait disturbance and hindlimb blood flow impairment in rat peripheral artery disease models. Eur J Pharmacol. 2012 Aug 15;689(1-3):132-8. doi: 10.1016/j.ejphar.2012.05.014. Epub 2012 May 31. PubMed PMID: 22659587.
2: Yoshida H, Ashikawa Y, Itoh S, Nakagawa T, Asanuma A, Tanabe S, Inoue Y, Hidaka H. K-134, a phosphodiesterase 3 inhibitor, prevents brain damage by inhibiting thrombus formation in a rat cerebral infarction model. PLoS One. 2012;7(10):e46432. doi: 10.1371/journal.pone.0046432. Epub 2012 Oct 23. PubMed PMID: 23110051; PubMed Central PMCID: PMC3479105.
3: Yoshida H, Itoh S, Hara T, Sasaki Y, Kondo S, Nakagawa T, Asanuma A, Tanabe S. A phosphodiesterase 3 inhibitor, K-134, improves hindlimb skeletal muscle circulation in rat models of peripheral arterial disease. Atherosclerosis. 2012 Mar;221(1):84-90. doi: 10.1016/j.atherosclerosis.2011.12.044. Epub 2012 Jan 5. PubMed PMID: 22269153.
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6: Ikenoya M, Doi T, Miura T, Sawanobori K, Nishio M, Hidaka H. Investigation of binding proteins for anti-platelet agent K-134 by Drug-Western method. Biochem Biophys Res Commun. 2007 Feb 23;353(4):1111-4. Epub 2006 Dec 29. PubMed PMID: 17207464.
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