WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 528814
CAS#: 1073616-61-1
Description: V-116517 is a TRPV1 antagonist potentially for the treatment of severe pain due to osteoarthritis and chronic pain due postherpetic neuralgia (PHN).
MedKoo Cat#: 528814
Name: V-116517
CAS#: 1073616-61-1
Chemical Formula: C19H18ClF3N4O3
Exact Mass: 442.102
Molecular Weight: 442.82
Elemental Analysis: C, 51.54; H, 4.10; Cl, 8.01; F, 12.87; N, 12.65; O, 10.84
Synonym: V-116517; V116517; V 116517
IUPAC/Chemical Name: (S)-3-chloro-5-(1,2-dihydroxyethyl)-N-(5-(trifluoromethyl)pyridin-2-yl)-3',6'-dihydro-[2,4'-bipyridine]-1'(2'H)-carboxamide
InChi Key: BMWVHVOIXZOJTJ-OAHLLOKOSA-N
InChi Code: InChI=1S/C19H18ClF3N4O3/c20-14-7-12(15(29)10-28)8-25-17(14)11-3-5-27(6-4-11)18(30)26-16-2-1-13(9-24-16)19(21,22)23/h1-3,7-9,15,28-29H,4-6,10H2,(H,24,26,30)/t15-/m1/s1
SMILES Code: O=C(N1CC=C(C2=NC=C([C@H](O)CO)C=C2Cl)CC1)NC3=NC=C(C(F)(F)F)C=C3
1: Arendt-Nielsen L, Harris S, Whiteside GT, Hummel M, Knappenberger T, OʼKeefe S, Kapil R, Kyle D. A randomized, double-blind, positive-controlled, 3-way cross-over human experimental pain study of a TRPV1 antagonist (V116517) in healthy volunteers and comparison with preclinical profile. Pain. 2016 Sep;157(9):2057-67. doi: 10.1097/j.pain.0000000000000610. PubMed PMID: 27168361.
2: Tafesse L, Kanemasa T, Kurose N, Yu J, Asaki T, Wu G, Iwamoto Y, Yamaguchi Y, Ni C, Engel J, Tsuno N, Patel A, Zhou X, Shintani T, Brown K, Hasegawa T, Shet M, Iso Y, Kato A, Kyle DJ. Structure-activity relationship studies and discovery of a potent transient receptor potential vanilloid (TRPV1) antagonist 4-[3-chloro-5-[(1S)-1,2-dihydroxyethyl]-2-pyridyl]-N-[5-(trifluoromethyl)-2-pyrid yl]-3,6-dihydro-2H-pyridine-1-carboxamide (V116517) as a clinical candidate for pain management. J Med Chem. 2014 Aug 14;57(15):6781-94. doi: 10.1021/jm500818a. Epub 2014 Aug 1. PubMed PMID: 25057800.