L838417 | CAS#286456-42-6

L838417
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532101

CAS#: 286456-42-6

Description: L838417 is a GABAA receptor modulator.

Chemical Structure

L838417

CAS# 286456-42-6

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 532101
Name: L838417
CAS#: 286456-42-6
Chemical Formula: C19H19F2N7O
Exact Mass: 399.16
Molecular Weight: 399.406
Elemental Analysis: C, 57.14; H, 4.80; F, 9.51; N, 24.55; O, 4.01

Price and Availability

Size	Price	Availability
5mg	USD 350	2 Weeks
25mg	USD 850	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: L838417; L 838417; L-838417.

IUPAC/Chemical Name: 5-({[7-tert-butyl-3-(2,5-difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]oxy}methyl)-1-methyl-1H-1,2,4-triazole

InChi Key: BQDUNOMMYOKHEP-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H19F2N7O/c1-19(2,3)13-8-15-24-25-17(12-7-11(20)5-6-14(12)21)28(15)26-18(13)29-9-16-22-10-23-27(16)4/h5-8,10H,9H2,1-4H3

SMILES Code: CN1N=CN=C1COC2=NN3C(C=C2C(C)(C)C)=NN=C3C4=CC(F)=CC=C4F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Instruction:

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Biological target:	L-838417 is a selective partial agonist at the α2, α3 and α5 subtypes of the GABAA receptor and an antagonist at the α1, with binding Ki values of 0.79 nM, 0.67 nM, 1.67 nM, 267 nM, 2.25 nM and 2183 nM for α1β3γ2, α2β3γ2, α3β3γ2, α4β3γ2, α5β3γ2 and α6β3γ2.
In vitro activity:	TBD
In vivo activity:	In Experiment 1, L-838,417 produced anxiolytic effects in rat adults at 1.0 mg/kg, as indexed by a transformation of social avoidance into preference and an increase in social investigation. Reference: Pharmacol Biochem Behav. 2013 Aug;109:31-7. https://pubmed.ncbi.nlm.nih.gov/23664899/

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	20.0	50.00

Preparing Stock Solutions

The following data is based on the product molecular weight 399.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	1. Morales M, Varlinskaya EI, Spear LP. Anxiolytic effects of the GABA(A) receptor partial agonist, L-838,417: impact of age, test context familiarity, and stress. Pharmacol Biochem Behav. 2013 Aug;109:31-7. doi: 10.1016/j.pbb.2013.05.004. Epub 2013 May 8. PMID: 23664899; PMCID: PMC3765038. 2. McMahon LR, France CP. Differential behavioral effects of low efficacy positive GABAA modulators in combination with benzodiazepines and a neuroactive steroid in rhesus monkeys. Br J Pharmacol. 2006 Feb;147(3):260-8. doi: 10.1038/sj.bjp.0706550. PMID: 16331290; PMCID: PMC1751295.
In vitro protocol:	TBD
In vivo protocol:	1. Morales M, Varlinskaya EI, Spear LP. Anxiolytic effects of the GABA(A) receptor partial agonist, L-838,417: impact of age, test context familiarity, and stress. Pharmacol Biochem Behav. 2013 Aug;109:31-7. doi: 10.1016/j.pbb.2013.05.004. Epub 2013 May 8. PMID: 23664899; PMCID: PMC3765038. 2. McMahon LR, France CP. Differential behavioral effects of low efficacy positive GABAA modulators in combination with benzodiazepines and a neuroactive steroid in rhesus monkeys. Br J Pharmacol. 2006 Feb;147(3):260-8. doi: 10.1038/sj.bjp.0706550. PMID: 16331290; PMCID: PMC1751295.

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1: Munro G, Ahring PK, Mirza NR. Developing analgesics by enhancing spinal inhibition after injury: GABAA receptor subtypes as novel targets. Trends Pharmacol Sci. 2009 Sep;30(9):453-9. doi: 10.1016/j.tips.2009.06.004. Review. PubMed PMID: 19729210.

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