L-759,633
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532085

CAS#: 174627-50-0

Description: L-759,633 is high affinity, selective CB2 receptor agonist (Ki values are 6.4 and 1043 nM for CB2 and CB1 receptors respectively). L-759,633 potently inhibits forskolin-stimulated cAMP production via CB2 receptors expressed in CHO cells (EC50 = 8.1 nM).


Price and Availability

Size
Price

5mg
USD 260
Size
Price

10mg
USD 440
Size
Price

25mg
USD 870

L-759,633, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 532085
Name: L-759,633
CAS#: 174627-50-0
Chemical Formula: C26H40O2
Exact Mass: 384.3028
Molecular Weight: 384.6
Elemental Analysis: C, 81.20; H, 10.48; O, 8.32


Synonym: L-759,633; L 759,633; L759633.

IUPAC/Chemical Name: (6aR,10aR)-1-methoxy-6,6,9-trimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromene

InChi Key: SUFMHSFGODDLKI-NHCUHLMSSA-N

InChi Code: InChI=1S/C26H40O2/c1-8-9-10-11-14-25(3,4)19-16-22(27-7)24-20-15-18(2)12-13-21(20)26(5,6)28-23(24)17-19/h12,16-17,20-21H,8-11,13-15H2,1-7H3/t20-,21-/m1/s1

SMILES Code: CC(C1=CC2=C(C(OC)=C1)[C@@](CC(C)=CC3)([H])[C@]3([H])C(C)(C)O2)(C)CCCCCC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Taylor L, Christou I, Kapellos TS, Buchan A, Brodermann MH, Gianella-Borradori M, Russell A, Iqbal AJ, Greaves DR. Primary Macrophage Chemotaxis Induced by Cannabinoid Receptor 2 Agonists Occurs Independently of the CB2 Receptor. Sci Rep. 2015 Jun 2;5:10682. doi: 10.1038/srep10682. PubMed PMID: 26033291; PubMed Central PMCID: PMC4451551.