L-745,870 Trihydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532080

CAS#: 866021-03-6 (3HCl)

Description: L-745,870 Trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist. L-745,870 has Ki values of 0.51, 2300 and 960 nM for D4, D3 and D2 subtypes respectively and > 1000-fold selectivity over 5-HT2, D1 and D5 receptors.


Price and Availability

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L745870 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 532080
Name: L-745,870 Trihydrochloride
CAS#: 866021-03-6 (3HCl)
Chemical Formula: C18H22Cl4N4
Exact Mass:
Molecular Weight: 436.2
Elemental Analysis: C, 49.56; H, 5.08; Cl, 32.51; N, 12.84


Related CAS #: 866021-03-6 (3HCl); 158985-00-3 (Free Base).  

Synonym: L-745,870 Trihydrochloride; L 745870 ; L-745870; L745870.

IUPAC/Chemical Name: 3-(4-[4-Chlorophenyl]piperazin-1-yl)-methyl-1H-pyrrolo[2,3-b]pyridine trihydrochloride

InChi Key: KJSOYZLYCFYXFC-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H19ClN4.3ClH/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18;;;/h1-7,12H,8-11,13H2,(H,20,21);3*1H

SMILES Code: ClC1=CC=C(N2CCN(CC3=CNC4=NC=CC=C43)CC2)C=C1.[H]Cl.[H]Cl.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Collins GT, Truccone A, Haji-Abdi F, Newman AH, Grundt P, Rice KC, Husbands SM, Greedy BM, Enguehard-Gueiffier C, Gueiffier A, Chen J, Wang S, Katz JL, Grandy DK, Sunahara RK, Woods JH. Proerectile effects of dopamine D2-like agonists are mediated by the D3 receptor in rats and mice. J Pharmacol Exp Ther. 2009 Apr;329(1):210-7. doi: 10.1124/jpet.108.144048. PubMed PMID: 19136638; PubMed Central PMCID: PMC2670592.

2: Beaulieu JM, Tirotta E, Sotnikova TD, Masri B, Salahpour A, Gainetdinov RR, Borrelli E, Caron MG. Regulation of Akt signaling by D2 and D3 dopamine receptors in vivo. J Neurosci. 2007 Jan 24;27(4):881-5. PubMed PMID: 17251429.

3: Melis MR, Succu S, Sanna F, Melis T, Mascia MS, Enguehard-Gueiffier C, Hubner H, Gmeiner P, Gueiffier A, Argiolas A. PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain. Eur J Neurosci. 2006 Oct;24(7):2021-30. PubMed PMID: 17067298.

4: Melis MR, Succu S, Mascia MS, Argiolas A. PD-168077, a selective dopamine D4 receptor agonist, induces penile erection when injected into the paraventricular nucleus of male rats. Neurosci Lett. 2005 Apr 29;379(1):59-62. PubMed PMID: 15814200.