WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 529112
CAS#: 235106-62-4
Description: VP-14637, also known as MDT 637, is a small molecule inhibitor of RSV that demonstrates antiviral activity with an EC50 value of 1.4 nM. VP-14637 inhibits respiratory syncytial virus fusion by similar mechanisms.
MedKoo Cat#: 529112
Name: VP-14637
CAS#: 235106-62-4
Chemical Formula: C25H22N10O3
Exact Mass: 510.1876
Molecular Weight: 510.518
Elemental Analysis: C, 58.82; H, 4.34; N, 27.44; O, 9.40
Synonym: MDT 637; MDT-637; MDT637; VP-14637; VP 14637; VP14637.
IUPAC/Chemical Name: 2-((2-hydroxy-5-((E)-((5-methyl-1H-tetrazol-1-yl)imino)methyl)phenyl)(4-hydroxyphenyl)methyl)-4-((Z)-((5-methyl-1H-tetrazol-1-yl)imino)methyl)phenol
InChi Key: BLUJRJMLDHEMRX-VVCLLGATSA-N
InChi Code: InChI=1S/C25H22N10O3/c1-15-28-30-32-34(15)26-13-17-3-9-23(37)21(11-17)25(19-5-7-20(36)8-6-19)22-12-18(4-10-24(22)38)14-27-35-16(2)29-31-33-35/h3-14,25,36-38H,1-2H3/b26-13-,27-14+
SMILES Code: OC1=CC=C(C(C2=CC(/C=N/N3C(C)=NN=N3)=CC=C2O)C4=CC(/C=N\N5N=NN=C5C)=CC=C4O)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 510.518 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Perron M, Stray K, Kinkade A, Theodore D, Lee G, Eisenberg E, Sangi M, Gilbert
BE, Jordan R, Piedra PA, Toms GL, Mackman R, Cihlar T. GS-5806 Inhibits a Broad
Range of Respiratory Syncytial Virus Clinical Isolates by Blocking the Virus-Cell
Fusion Process. Antimicrob Agents Chemother. 2015 Dec 14;60(3):1264-73. doi:
10.1128/AAC.01497-15. PubMed PMID: 26666922; PubMed Central PMCID: PMC4776015.
2: Del Vecchio AM, Sarisky RT. Cold virus fusion or stopping fusion
cold--inhibitors of the human respiratory syncytial virus F protein. Recent Pat
Antiinfect Drug Discov. 2006 Jun;1(2):247-54. Review. PubMed PMID: 18221150.
3: Douglas JL, Panis ML, Ho E, Lin KY, Krawczyk SH, Grant DM, Cai R, Swaminathan
S, Chen X, Cihlar T. Small molecules VP-14637 and JNJ-2408068 inhibit respiratory
syncytial virus fusion by similar mechanisms. Antimicrob Agents Chemother. 2005
Jun;49(6):2460-6. PubMed PMID: 15917547; PubMed Central PMCID: PMC1140497.
4: Douglas JL, Panis ML, Ho E, Lin KY, Krawczyk SH, Grant DM, Cai R, Swaminathan
S, Cihlar T. Inhibition of respiratory syncytial virus fusion by the small
molecule VP-14637 via specific interactions with F protein. J Virol. 2003
May;77(9):5054-64. PubMed PMID: 12692208; PubMed Central PMCID: PMC153948.
5: De Clercq E. Highlights in the development of new antiviral agents. Mini Rev
Med Chem. 2002 Apr;2(2):163-75. Review. PubMed PMID: 12370077.
6: McKimm-Breschkin J. VP-14637 ViroPharma. Curr Opin Investig Drugs. 2000
Dec;1(4):425-7. PubMed PMID: 11249694.
