VP-14637 | CAS#235106-62-4 | viral fusion protein inhibitor

VP-14637
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 529112

CAS#: 235106-62-4

Description: VP-14637, also known as MDT 637, is a small molecule inhibitor of RSV that demonstrates antiviral activity with an EC50 value of 1.4 nM. VP-14637 inhibits respiratory syncytial virus fusion by similar mechanisms.

Chemical Structure

VP-14637

CAS# 235106-62-4

Instruction

Theoretical Analysis

MedKoo Cat#: 529112
Name: VP-14637
CAS#: 235106-62-4
Chemical Formula: C25H22N10O3
Exact Mass: 510.19
Molecular Weight: 510.518
Elemental Analysis: C, 58.82; H, 4.34; N, 27.44; O, 9.40

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 320
10mg	USD 540
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: MDT 637; MDT-637; MDT637; VP-14637; VP 14637; VP14637.

IUPAC/Chemical Name: 2-((2-hydroxy-5-((E)-((5-methyl-1H-tetrazol-1-yl)imino)methyl)phenyl)(4-hydroxyphenyl)methyl)-4-((Z)-((5-methyl-1H-tetrazol-1-yl)imino)methyl)phenol

InChi Key: BLUJRJMLDHEMRX-VVCLLGATSA-N

InChi Code: InChI=1S/C25H22N10O3/c1-15-28-30-32-34(15)26-13-17-3-9-23(37)21(11-17)25(19-5-7-20(36)8-6-19)22-12-18(4-10-24(22)38)14-27-35-16(2)29-31-33-35/h3-14,25,36-38H,1-2H3/b26-13-,27-14+

SMILES Code: OC1=CC=C(C(C2=CC(/C=N/N3C(C)=NN=N3)=CC=C2O)C4=CC(/C=N\N5N=NN=C5C)=CC=C4O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 510.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Perron M, Stray K, Kinkade A, Theodore D, Lee G, Eisenberg E, Sangi M, Gilbert
BE, Jordan R, Piedra PA, Toms GL, Mackman R, Cihlar T. GS-5806 Inhibits a Broad
Range of Respiratory Syncytial Virus Clinical Isolates by Blocking the Virus-Cell
Fusion Process. Antimicrob Agents Chemother. 2015 Dec 14;60(3):1264-73. doi:
10.1128/AAC.01497-15. PubMed PMID: 26666922; PubMed Central PMCID: PMC4776015.

2: Del Vecchio AM, Sarisky RT. Cold virus fusion or stopping fusion
cold--inhibitors of the human respiratory syncytial virus F protein. Recent Pat
Antiinfect Drug Discov. 2006 Jun;1(2):247-54. Review. PubMed PMID: 18221150.

3: Douglas JL, Panis ML, Ho E, Lin KY, Krawczyk SH, Grant DM, Cai R, Swaminathan
S, Chen X, Cihlar T. Small molecules VP-14637 and JNJ-2408068 inhibit respiratory
syncytial virus fusion by similar mechanisms. Antimicrob Agents Chemother. 2005
Jun;49(6):2460-6. PubMed PMID: 15917547; PubMed Central PMCID: PMC1140497.

4: Douglas JL, Panis ML, Ho E, Lin KY, Krawczyk SH, Grant DM, Cai R, Swaminathan
S, Cihlar T. Inhibition of respiratory syncytial virus fusion by the small
molecule VP-14637 via specific interactions with F protein. J Virol. 2003
May;77(9):5054-64. PubMed PMID: 12692208; PubMed Central PMCID: PMC153948.

5: De Clercq E. Highlights in the development of new antiviral agents. Mini Rev
Med Chem. 2002 Apr;2(2):163-75. Review. PubMed PMID: 12370077.

6: McKimm-Breschkin J. VP-14637 ViroPharma. Curr Opin Investig Drugs. 2000
Dec;1(4):425-7. PubMed PMID: 11249694.

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VP-14637 featured