L-168,049
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532054

CAS#: 191034-25-0

Description: L-168,049 is a non-peptidyl human glucagon receptor antagonist.


Chemical Structure

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L-168,049
CAS# 191034-25-0

Theoretical Analysis

MedKoo Cat#: 532054
Name: L-168,049
CAS#: 191034-25-0
Chemical Formula: C24H20BrClN2O
Exact Mass: 466.0448
Molecular Weight:
Elemental Analysis: C, 61.62; H, 4.31; Br, 17.08; Cl, 7.58; N, 5.99; O, 3.42

Price and Availability

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5.0mg USD 300.0 2 Weeks
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Synonym: L-168,049; L 168,049; L168,049.

IUPAC/Chemical Name: 4-[3-(5-bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]pyridine

InChi Key: HHBOWXZOLYQFNY-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H20BrClN2O/c1-2-13-29-23-8-5-18(25)14-20(23)21-15-22(16-3-6-19(26)7-4-16)28-24(21)17-9-11-27-12-10-17/h3-12,14-15,28H,2,13H2,1H3

SMILES Code: ClC1=CC=C(C2=CC(C3=CC(Br)=CC=C3OCCC)=C(C4=CC=NC=C4)N2)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Yu R, Chen CR, Liu X, Kodra JT. Rescue of a pathogenic mutant human glucagon receptor by pharmacological chaperones. J Mol Endocrinol. 2012 Jul 25;49(2):69-78. doi: 10.1530/JME-12-0051. PubMed PMID: 22693263.

2: Elson AE, Dotson CD, Egan JM, Munger SD. Glucagon signaling modulates sweet taste responsiveness. FASEB J. 2010 Oct;24(10):3960-9. doi: 10.1096/fj.10-158105. PubMed PMID: 20547661; PubMed Central PMCID: PMC2996909.

3: Dallas-Yang Q, Qureshi SA, Xie D, Zhang BB, Jiang G. Detection of glucagon-dependent GTPgammaS binding in high-throughput format. Anal Biochem. 2002 Feb 1;301(1):156-9. PubMed PMID: 11811981.

4: Shiao LL, Cascieri MA, Trumbauer M, Chen H, Sullivan KA. Generation of mice expressing the human glucagon receptor with a direct replacement vector. Transgenic Res. 1999 Aug;8(4):295-302. PubMed PMID: 10621976.

5: de Laszlo SE, Hacker C, Li B, Kim D, MacCoss M, Mantlo N, Pivnichny JV, Colwell L, Koch GE, Cascieri MA, Hagmann WK. Potent, orally absorbed glucagon receptor antagonists. Bioorg Med Chem Lett. 1999 Mar 8;9(5):641-6. PubMed PMID: 10201821.

6: Cascieri MA, Koch GE, Ber E, Sadowski SJ, Louizides D, de Laszlo SE, Hacker C, Hagmann WK, MacCoss M, Chicchi GG, Vicario PP. Characterization of a novel, non-peptidyl antagonist of the human glucagon receptor. J Biol Chem. 1999 Mar 26;274(13):8694-7. PubMed PMID: 10085108.