WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 532051
CAS#: 151488-11-8
Description: L-162,313 is a non-peptide AT1 receptor agonist.
MedKoo Cat#: 532051
Name: L-162,313
CAS#: 151488-11-8
Chemical Formula: C30H38N4O4S2
Exact Mass: 582.2334
Molecular Weight: 582.78
Elemental Analysis: C, 61.83; H, 6.57; N, 9.61; O, 10.98; S, 11.00
This product is not in stock, which may be available by custom synthesis.
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Note: Price will be listed if it is available in the future.
Synonym: L-162,313; L 162,313; L162,313; L-162313.
IUPAC/Chemical Name: butyl N-[3-[4-[(2-ethyl-5,7-dimethylimidazo[5,4-b]pyridin-3-yl)methyl]phenyl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylcarbamate
InChi Key: RINPELQWLUGERM-UHFFFAOYSA-N
InChi Code: InChI=1S/C30H38N4O4S2/c1-7-9-14-38-30(35)33-40(36,37)29-25(17-24(39-29)15-19(3)4)23-12-10-22(11-13-23)18-34-26(8-2)32-27-20(5)16-21(6)31-28(27)34/h10-13,16-17,19H,7-9,14-15,18H2,1-6H3,(H,33,35)
SMILES Code: O=C(OCCCC)NS(=O)(C1=C(C2=CC=C(CN3C(CC)=NC4=C(C)C=C(C)N=C43)C=C2)C=C(CC(C)C)S1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 582.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Steckelings UM, Larhed M, Hallberg A, Widdop RE, Jones ES, Wallinder C, Namsolleck P, Dahlöf B, Unger T. Non-peptide AT2-receptor agonists. Curr Opin Pharmacol. 2011 Apr;11(2):187-92. doi: 10.1016/j.coph.2010.11.002. Review. PubMed PMID: 21167778.
2: Wu X, Kihara T, Hongo H, Akaike A, Niidome T, Sugimoto H. Angiotensin receptor type 1 antagonists protect against neuronal injury induced by oxygen-glucose depletion. Br J Pharmacol. 2010 Sep;161(1):33-50. doi: 10.1111/j.1476-5381.2010.00840.x. PubMed PMID: 20718738; PubMed Central PMCID: PMC2962815.
3: Tadevosyan A, Maguy A, Villeneuve LR, Babin J, Bonnefoy A, Allen BG, Nattel S. Nuclear-delimited angiotensin receptor-mediated signaling regulates cardiomyocyte gene expression. J Biol Chem. 2010 Jul 16;285(29):22338-49. doi: 10.1074/jbc.M110.121749. PubMed PMID: 20463030; PubMed Central PMCID: PMC2903375.
