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MedKoo CAT#: 528210

CAS#: 891824-47-8

Description: VCH-286 is a C-C chemokine receptor type 5 (CCR5) receptor antagonist potentially for the treatment of HIV infection. Although VCH-286 used alone had highly inhibitory activity, paired combinations with different drug classes led to synergistic or additive interactions. However, combinations with other CCR5 inhibitors led to effects ranging from synergy to antagonism.

Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-07-11. Prices are subject to change without notice.

VCH-286 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 528210
Name: VCH-286
CAS#: 891824-47-8
Chemical Formula: C34H50F2N4O3
Exact Mass: 600.3851
Molecular Weight: 600.7958
Elemental Analysis: C, 67.97; H, 8.39; F, 6.32; N, 9.33; O, 7.99

Synonym: VCH-286; VCH 286; VCH286

IUPAC/Chemical Name: 4,4-difluoro-N-((S)-3-((1R,3R,5S)-3'-isopropyl-2'-oxo-1'-((tetrahydro-2H-pyran-4-yl)methyl)-8-azaspiro[bicyclo[3.2.1]octane-3,4'-imidazolidin]-8-yl)-1-phenylpropyl)cyclohexane-1-carboxamide


InChi Code: InChI=1S/C34H50F2N4O3/c1-24(2)40-32(42)38(22-25-13-18-43-19-14-25)23-33(40)20-28-8-9-29(21-33)39(28)17-12-30(26-6-4-3-5-7-26)37-31(41)27-10-15-34(35,36)16-11-27/h3-7,24-25,27-30H,8-23H2,1-2H3,(H,37,41)/t28-,29+,30-,33-/m0/s1


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Asin-Milan O, Sylla M, El-Far M, Belanger-Jasmin G, Haidara A, Blackburn J, Chamberland A, Tremblay CL. Synergistic combinations of the CCR5 inhibitor VCH-286 with other classes of HIV-1 inhibitors. Antimicrob Agents Chemother. 2014 Dec;58(12):7565-9. doi: 10.1128/AAC.03630-14. PubMed PMID: 25267674; PubMed Central PMCID: PMC4249518.