JP-1302 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531990

CAS#: 1259314-65-2 (HCl)

Description: JP 1302 dihydrochloride is a α2C-adrenoceptor antagonist that displays ~ 50-fold selectivity over other α2-adrenoceptor subtypes (Ki values are 28, 1470, 1700 and 3150 nM for human α2C, α2B, α2D and α2A subtypes respectively). JP 1302 dihydrochloride potently antagonizes adrenalin-stimulated 35GTPγS binding in vitro (KB = 16 nM) and produces antidepressant and antipsychotic-like effects in vivo.

Chemical Structure

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JP-1302 HCl
CAS# 1259314-65-2 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 531990
Name: JP-1302 HCl
CAS#: 1259314-65-2 (HCl)
Chemical Formula: C24H26Cl2N4
Exact Mass: 0.00
Molecular Weight: 441.400
Elemental Analysis: C, 65.31; H, 5.94; Cl, 16.06; N, 12.69

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 1259314-65-2 (HCl)   80259-18-3 (free Base)    

Synonym: JP 1302 dihydrochloride; JP-1302 HCl; JP1302; JP-1302; JP 1302.

IUPAC/Chemical Name: N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinamine dihydrochloride

InChi Key: VVZOADYFJAJZGL-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H24N4.2ClH/c1-27-14-16-28(17-15-27)19-12-10-18(11-13-19)25-24-20-6-2-4-8-22(20)26-23-9-5-3-7-21(23)24;;/h2-13H,14-17H2,1H3,(H,25,26);2*1H

SMILES Code: CN1CCN(C2=CC=C(NC3=C(C=CC=C4)C4=NC5=CC=CC=C53)C=C2)CC1.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 441.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Nakamura M, Suk K, Lee MG, Jang IS. α(2A) adrenoceptor-mediated presynaptic inhibition of GABAergic transmission in rat tuberomammillary nucleus neurons. J Neurochem. 2013 Jun;125(6):832-42. doi: 10.1111/jnc.12259. PubMed PMID: 23570239.