JNJ-5207787
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MedKoo CAT#: 531989

CAS#: 683746-68-1

Description: JNJ-5207787 is a small molecule antagonist of the neuropeptide Y Y2 receptor.


Chemical Structure

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JNJ-5207787
CAS# 683746-68-1

Theoretical Analysis

MedKoo Cat#: 531989
Name: JNJ-5207787
CAS#: 683746-68-1
Chemical Formula: C32H38N4O2
Exact Mass: 510.2995
Molecular Weight: 510.68
Elemental Analysis: C, 75.26; H, 7.50; N, 10.97; O, 6.27

Price and Availability

Size Price Availability Quantity
5.0mg USD 280.0 2 Weeks
10.0mg USD 490.0 2 Weeks
50.0mg USD 1420.0 2 Weeks
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Synonym: JNJ-5207787; JNJ 5207787; JNJ5207787.

IUPAC/Chemical Name: (E)-N-(1-acetyl-2,3-dihydroindol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)piperidin-4-yl]prop-2-enamide

InChi Key: DSEJCLDJIFTPPH-FMIVXFBMSA-N

InChi Code: InChI=1S/C32H38N4O2/c1-24(37)35-20-14-28-10-11-30(22-31(28)35)36(32(38)12-9-26-7-4-8-27(21-26)23-33)29-15-18-34(19-16-29)17-13-25-5-2-3-6-25/h4,7-12,21-22,25,29H,2-3,5-6,13-20H2,1H3/b12-9+

SMILES Code: O=C(N(C1=CC2=C(C=C1)CCN2C(C)=O)C3CCN(CCC4CCCC4)CC3)/C=C/C5=CC=CC(C#N)=C5

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 510.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Mittapalli GK, Roberts E. Ligands of the neuropeptide Y Y2 receptor. Bioorg Med Chem Lett. 2014 Jan 15;24(2):430-41. doi: 10.1016/j.bmcl.2013.11.061. Review. PubMed PMID: 24365162; PubMed Central PMCID: PMC4672871.

2: Bonaventure P, Nepomuceno D, Mazur C, Lord B, Rudolph DA, Jablonowski JA, Carruthers NI, Lovenberg TW. Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-eth yl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y2 receptor. J Pharmacol Exp Ther. 2004 Mar;308(3):1130-7. PubMed PMID: 14617685.