JNJ16259685
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MedKoo CAT#: 531980

CAS#: 409345-29-5

Description: JNJ16259685 is a potent, non-competitive mGlu1 antagonist (Ki = 0.34 nM). JNJ16259685 inhibits glutamate-induced Ca2+ response at the human mGlu1 receptor with an IC50 value of 0.55 nM. JNJ16259685 is selective over mGlu5 (> 400-fold) and displays no activity at mGlu2, mGlu3, mGlu4, mGlu6, AMPA or NMDA receptors (IC50 > 10 μM).


Chemical Structure

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JNJ16259685
CAS# 409345-29-5

Theoretical Analysis

MedKoo Cat#: 531980
Name: JNJ16259685
CAS#: 409345-29-5
Chemical Formula: C20H23NO3
Exact Mass: 325.1678
Molecular Weight: 325.41
Elemental Analysis: C, 73.82; H, 7.12; N, 4.30; O, 14.75

Price and Availability

Size Price Availability Quantity
50.0mg USD 450.0 2 Weeks
100.0mg USD 850.0 2 Weeks
200.0mg USD 1450.0 2 Weeks
500.0mg USD 2150.0 2 Weeks
1.0g USD 2950.0 2 Weeks
2.0g USD 5450.0 2 Weeks
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Synonym: JNJ16259685; JNJ 16259685; JNJ-16259685.

IUPAC/Chemical Name: (3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl)(4-methoxycyclohexyl)methanone

InChi Key: QOTAQTRFJWLFCR-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H23NO3/c1-23-17-7-4-13(5-8-17)19(22)14-6-9-18-16(11-14)12-15-3-2-10-24-20(15)21-18/h6,9,11-13,17H,2-5,7-8,10H2,1H3

SMILES Code: O=C(C1=CC=C2N=C3C(CCCO3)=CC2=C1)C4CCC(OC)CC4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 325.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Hodgson RA, Hyde LA, Guthrie DH, Cohen-Williams ME, Leach PT, Kazdoba TM, Bleickardt CJ, Lu SX, Parker EM, Varty GB. Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination. Pharmacol Biochem Behav. 2011 Apr;98(2):181-7. doi: 10.1016/j.pbb.2010.11.018. PubMed PMID: 21122808.

2: Navarro JF, De Castro V, Martín-López M. JNJ16259685, a selective mGlu1 antagonist, suppresses isolation-induced aggression in male mice. Eur J Pharmacol. 2008 May 31;586(1-3):217-20. doi: 10.1016/j.ejphar.2008.02.070. PubMed PMID: 18367165.

3: Fukunaga I, Yeo CH, Batchelor AM. Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices. Br J Pharmacol. 2007 Jul;151(6):870-6. PubMed PMID: 17502847; PubMed Central PMCID: PMC2014124.

4: Lavreysen H, Wouters R, Bischoff F, Nóbrega Pereira S, Langlois X, Blokland S, Somers M, Dillen L, Lesage AS. JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist. Neuropharmacology. 2004 Dec;47(7):961-72. PubMed PMID: 15555631.