WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 531964
Description: ICA-27243 is a novel, potent and selective activator of M-current and KCNQ2/Q3 channels. ICA-27243 enhances KCNQ channel activation by shifting channel opening to more hyperpolarized potentials.
MedKoo Cat#: 531964
Chemical Formula: C12H7ClF2N2O
Exact Mass: 268.0215
Molecular Weight: 268.65
Elemental Analysis: C, 53.65; H, 2.63; Cl, 13.20; F, 14.14; N, 10.43; O, 5.96
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: ICA-27243; ICA 27243; ICA27243.
IUPAC/Chemical Name: N-(6-chloropyridin-3-yl)-3,4-difluorobenzamide
InChi Key: GDGUOCFTHNGPBK-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H7ClF2N2O/c13-11-4-2-8(6-16-11)17-12(18)7-1-3-9(14)10(15)5-7/h1-6H,(H,17,18)
SMILES Code: O=C(NC1=CC=C(Cl)N=C1)C2=CC=C(F)C(F)=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 268.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Sander SE, Lambrecht C, Richter A. The K(V)7.2/3 preferring channel opener ICA 27243 attenuates L-DOPA-induced dyskinesia in hemiparkinsonian rats. Neurosci Lett. 2013 Jun 17;545:59-63. doi: 10.1016/j.neulet.2013.04.017. PubMed PMID: 23623937.
2: Blom SM, Schmitt N, Jensen HS. Differential effects of ICA-27243 on cloned K(V)7 channels. Pharmacology. 2010;86(3):174-81. doi: 10.1159/000317525. PubMed PMID: 20714208.
3: Padilla K, Wickenden AD, Gerlach AC, McCormack K. The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site. Neurosci Lett. 2009 Nov 13;465(2):138-42. doi: 10.1016/j.neulet.2009.08.071. PubMed PMID: 19733209.
4: Roeloffs R, Wickenden AD, Crean C, Werness S, McNaughton-Smith G, Stables J, McNamara JO, Ghodadra N, Rigdon GC. In vivo profile of ICA-27243 [N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a potent and selective KCNQ2/Q3 (Kv7.2/Kv7.3) activator in rodent anticonvulsant models. J Pharmacol Exp Ther. 2008 Sep;326(3):818-28. doi: 10.1124/jpet.108.137794. PubMed PMID: 18577704.
5: Wickenden AD, Krajewski JL, London B, Wagoner PK, Wilson WA, Clark S, Roeloffs R, McNaughton-Smith G, Rigdon GC. N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. Mol Pharmacol. 2008 Mar;73(3):977-86. PubMed PMID: 18089837.