IBC 293
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531961

CAS#: 306935-41-1

Description: IBC 293 is a highly selective agonist for GPR109B (HM74), human orphan G-protein-coupled receptor expressed in adipocytes. IBC 293 is selective for GPR109B over niacin receptor GPR109A (HM74A).


Chemical Structure

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IBC 293
CAS# 306935-41-1

Theoretical Analysis

MedKoo Cat#: 531961
Name: IBC 293
CAS#: 306935-41-1
Chemical Formula: C10H11N3O2
Exact Mass: 205.09
Molecular Weight: 205.217
Elemental Analysis: C, 58.53; H, 5.40; N, 20.48; O, 15.59

Price and Availability

Size Price Availability Quantity
1g USD 250 2 Weeks
5g USD 650 2 Weeks
10g USD 950 2 Weeks
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Synonym: IBC 293; IBC293; IBC-293.

IUPAC/Chemical Name: 1-propan-2-ylbenzotriazole-5-carboxylic acid

InChi Key: RUTVRAJKELSHCC-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H11N3O2/c1-6(2)13-9-4-3-7(10(14)15)5-8(9)11-12-13/h3-6H,1-2H3,(H,14,15)

SMILES Code: O=C(C1=CC=C(N(C(C)C)N=N2)C2=C1)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: A selective agonist of GPR109B.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMF 16.0 77.97
DMF:PBS (pH 7.2) (1:1) 0.5 2.44
DMSO 25.0 121.82
Ethanol 5.0 24.36

Preparing Stock Solutions

The following data is based on the product molecular weight 205.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1: Mazzola E, Cheng SC, Parmigiani G. The penetrance of ductal carcinoma in situ among BRCA1 and BRCA2 mutation carriers. Breast Cancer Res Treat. 2013 Jan;137(1):315-8. doi: 10.1007/s10549-012-2345-5. PubMed PMID: 23184082; PubMed Central PMCID: PMC3836600.