H2L5186303
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531950

CAS#: 139262-76-3

Description: H2L5186303 is a potent and selective lysophosphatidic acid 2 (LPA2) receptor antagonist (IC50 values are 8.9, 1230 and 27354 nM).


Chemical Structure

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H2L5186303
CAS# 139262-76-3

Theoretical Analysis

MedKoo Cat#: 531950
Name: H2L5186303
CAS#: 139262-76-3
Chemical Formula: C26H20N2O6
Exact Mass: 456.1321
Molecular Weight: 456.45
Elemental Analysis: C, 68.42; H, 4.42; N, 6.14; O, 21.03

Price and Availability

Size Price Availability Quantity
5.0mg USD 310.0 2 Weeks
10.0mg USD 550.0 2 Weeks
25.0mg USD 950.0 2 Weeks
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Synonym: H2L5186303; H2L 5186303; H2L-5186303.

IUPAC/Chemical Name: (Z)-4-oxo-N-[4-[3-[4-[[(Z)-4-oxobut-2-enoyl]amino]phenoxy]phenoxy]phenyl]but-2-enamide

InChi Key: BFNFDDZOFCRJTI-PORYWJCVSA-N

InChi Code: InChI=1S/C26H20N2O6/c29-16-2-6-25(31)27-19-8-12-21(13-9-19)33-23-4-1-5-24(18-23)34-22-14-10-20(11-15-22)28-26(32)7-3-17-30/h1-18H,(H,27,31)(H,28,32)/b6-2-,7-3-

SMILES Code: O=C(NC1=CC=C(OC2=CC=CC(OC3=CC=C(NC(/C=C\C=O)=O)C=C3)=C2)C=C1)/C=C\C=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 456.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Fells JI, Tsukahara R, Liu J, Tigyi G, Parrill AL. Structure-based drug design identifies novel LPA3 antagonists. Bioorg Med Chem. 2009 Nov 1;17(21):7457-64. doi: 10.1016/j.bmc.2009.09.022. PubMed PMID: 19800804; PubMed Central PMCID: PMC2771199.