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MedKoo CAT#: 527727

CAS#: 1645260-76-9

Description: DA-6886 is a 5-Hydroxytryptamine receptor 4 (5-HT4) agonist potentially for the treatment of irritable bowel syndrome. DA-6886 induced relaxation of the rat oesophagus preparation in a 5-HT4 receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressing hERG channels revealed that it inhibited hERG channel current with an pIC50 value of 4.3, indicating that the compound was 1000-fold more selective for the 5-HT4 receptor over hERG channels.

Price and Availability

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Pricing updated 2020-07-14. Prices are subject to change without notice.

DA-6886 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 527727
Name: DA-6886
CAS#: 1645260-76-9
Chemical Formula: C19H28Cl2N6O2
Exact Mass:
Molecular Weight: 443.373
Elemental Analysis: C, 51.47; H, 6.37; Cl, 15.99; N, 18.96; O, 7.22

Related CAS #: 1645260-76-9 (HCl); 1342815-16-0 (free base)  

Synonym: DA-6886; DA 6886; DA6886

IUPAC/Chemical Name: N-((1-(3-(1H-1,2,3-triazol-1-yl)propyl)piperidin-4-yl)methyl)-4-amino-5-chloro-2-methoxybenzamide hydrochloride


InChi Code: InChI=1S/C19H27ClN6O2.ClH/c1-28-18-12-17(21)16(20)11-15(18)19(27)22-13-14-3-8-25(9-4-14)6-2-7-26-10-5-23-24-26;/h5,10-12,14H,2-4,6-9,13,21H2,1H3,(H,22,27);1H


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Lee MJ, Cho KH, Park HM, Sung HJ, Choi S, Im W. Pharmacological profile of DA-6886, a novel 5-HT4 receptor agonist to accelerate colonic motor activity in mice. Eur J Pharmacol. 2014 Jul 15;735:115-22. doi: 10.1016/j.ejphar.2014.03.061. PubMed PMID: 24769304.