WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 527720
CAS#: 925438-34-2
Description: ACP-0052, also known as SL-052 and ACP-SL-052, is a hypocrellin-based photosensitizer potentially for the treatment of prostate cancer.
MedKoo Cat#: 527720
Name: ACP-0052
CAS#: 925438-34-2
Chemical Formula: C35H32N2O7
Exact Mass: 592.221
Molecular Weight: 592.648
Elemental Analysis: C, 70.93; H, 5.44; N, 4.73; O, 18.90
This product is not in stock, which may be available by custom synthesis.
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Synonym: ACP-0052; ACP 0052; ACP0052; SL-052; SL052; SL 052; ACP-SL-052; ACP SL 052; ACPSL052
IUPAC/Chemical Name: 17-acetyl-2-hydroxy-1,5,6-trimethoxy-16-methyl-9a,10,11,12,13,13a,14,17-octahydro-3H-cyclohepta[12,1]peryleno[2,3-b]quinoxaline-3,8(9H)-dione
InChi Key: BSDCXVHKKRVTFB-UHFFFAOYSA-N
InChi Code: InChI=1S/C35H32N2O7/c1-13-10-15-23-28-24(33-32(15)36-16-8-6-7-9-17(16)37-33)18(39)11-20(42-3)26(28)27-21(43-4)12-19(40)25-30(27)29(23)31(22(13)14(2)38)35(44-5)34(25)41/h10-12,16-17,22,36-37,41H,6-9H2,1-5H3
SMILES Code: O=C(C1=C(O)C(OC)=C2C(C(C)=O)C(C)=C3)C=C(OC)C4=C1C2=C5C3=C6NC7CCCCC7NC6=C8C(C=C(OC)C4=C58)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 592.648 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Korbelik M, Madiyalakan R, Woo T, Haddadi A. Antitumor efficacy of photodynamic therapy using novel nanoformulations of hypocrellin photosensitizer SL052. Photochem Photobiol. 2012 Jan-Feb;88(1):188-93. doi: 10.1111/j.1751-1097.2011.01035.x. PubMed PMID: 22070614.
2: Meng Y, Zou C, Madiyalakan R, Woo T, Huang M, Yang X, Swanson E, Chen J, Xing JZ. Water-soluble and biocompatible sono/photosensitizer nanoparticles for enhanced cancer therapy. Nanomedicine (Lond). 2010 Dec;5(10):1559-69. doi: 10.2217/nnm.10.91. PubMed PMID: 21143033.
3: Xiao Z, Owen RJ, Liu W, Tulip J, Brown K, Woo T, Moore RB. Lipophilic photosensitizer administration via the prostate arteries for photodynamic therapy of the canine prostate. Photodiagnosis Photodyn Ther. 2010 Jun;7(2):106-14. doi: 10.1016/j.pdpdt.2010.03.003. PubMed PMID: 20510305.
