LYS01 free base
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MedKoo CAT#: 407398

CAS#: 1391426-22-4 (free base)

Description: LYS01 free base is a new lysosomal autophagy inhibitor. Lys01 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency. The trihydydrochloride salt of LYS01 is called LYS05. Lys05, a water-soluble salt of Lys01, more potently accumulates within and deacidifies the lysosome, resulting in impaired autophagy and tumor growth.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 150 Same day
25mg USD 250 Same day
50mg USD 450 Same day
100mg USD 650 Same day
200mg USD 950 Same day
500mg USD 1650 Same day
1g USD 2650 Same day
2g USD 3850 Same day
5g USD 5750 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-25. Prices are subject to change without notice.

Lys01(free base), purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407398
Name: LYS01 free base
CAS#: 1391426-22-4 (free base)
Chemical Formula: C23H23Cl2N5
Exact Mass: 439.1331
Molecular Weight: 440.372
Elemental Analysis: C, 62.73; H, 5.26; Cl, 16.10; N, 15.90


Related CAS #: 1391426-24-6 (HCl)   1391426-22-4 (free base)  

Synonym: LYS01; LYS-01; LYS 01

IUPAC/Chemical Name: N2-(7-Chloro-4-quinolinyl)-N1-[2-[(7-chloro-4-quinolinyl)amino]ethyl]-N1-methyl-1,2-ethanediamine

InChi Key: WDGQVCRQXSYPCW-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H23Cl2N5/c1-30(12-10-28-20-6-8-26-22-14-16(24)2-4-18(20)22)13-11-29-21-7-9-27-23-15-17(25)3-5-19(21)23/h2-9,14-15H,10-13H2,1H3,(H,26,28)(H,27,29)

SMILES Code: CN(CCNC1=CC=NC2=CC(Cl)=CC=C12)CCNC3=CC=NC4=CC(Cl)=CC=C34


Technical Data

Appearance:
White to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Amaravadi RK, Winkler JD. Lys05: a new lysosomal autophagy inhibitor.
Autophagy. 2012 Sep;8(9):1383-4. doi: 10.4161/auto.20958. PubMed PMID: 22878685;
PubMed Central PMCID: PMC3442884.

2: McAfee Q, Zhang Z, Samanta A, Levi SM, Ma XH, Piao S, Lynch JP, Uehara T,
Sepulveda AR, Davis LE, Winkler JD, Amaravadi RK. Autophagy inhibitor Lys05 has
single-agent antitumor activity and reproduces the phenotype of a genetic
autophagy deficiency. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8253-8. doi:
10.1073/pnas.1118193109. PubMed PMID: 22566612; PubMed Central PMCID: PMC3361415.

3: DeVorkin L, Hattersley M, Kim P, Ries J, Spowart J, Anglesio MS, Levi SM,
Huntsman DG, Amaravadi RK, Winkler JD, Tinker AV, Lum JJ. Autophagy Inhibition
Enhances Sunitinib Efficacy in Clear Cell Ovarian Carcinoma. Mol Cancer Res. 2016
Dec 7. pii: molcanres.0132.2016. [Epub ahead of print] PubMed PMID: 27927774.

4: Shi TT, Yu XX, Yan LJ, Xiao HT. Research progress of hydroxychloroquine and
autophagy inhibitors on cancer. Cancer Chemother Pharmacol. 2016 Nov 26. [Epub
ahead of print] Review. PubMed PMID: 27889812.