WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 529413

CAS#: 172649-40-0

Description: ZD-0947, also known as AZD-0947, is a K(ATP) channel activator potentially for the treatment of overactive bladder (OAB).

Chemical Structure

CAS# 172649-40-0

Theoretical Analysis

MedKoo Cat#: 529413
Name: ZD-0947
CAS#: 172649-40-0
Chemical Formula: C17H13F3N2O
Exact Mass: 318.098
Molecular Weight: 318.2992
Elemental Analysis: C, 64.15; H, 4.12; F, 17.91; N, 8.80; O, 5.03

Price and Availability

Size Price Availability Quantity
5.0mg USD 285.0 2 Weeks
25.0mg USD 1000.0 2 Weeks
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Synonym: ZD-0947; AZD-0947; ZD0947; AZD0947; ZD 0947; AZD 0947

IUPAC/Chemical Name: Benzonitrile, 3-(1,4,5,6,7,8-hexahydro-5-oxo-2-(trifluoromethyl)-4-quinolinyl)-, (S)-


InChi Code: InChI=1S/C17H13F3N2O/c18-17(19,20)15-8-12(11-4-1-3-10(7-11)9-21)16-13(22-15)5-2-6-14(16)23/h1,3-4,7-8,12,22H,2,5-6H2/t12-/m0/s1

SMILES Code: N#CC1=CC=CC([C@@H]2C=C(C(F)(F)F)NC3=C2C(CCC3)=O)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 318.2992 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Mori K, Yamashita Y, Teramoto N. Effects of ZD0947, a novel and potent ATP-sensitive K(+) channel opener, on smooth muscle-type ATP-sensitive K(+) channels. Eur J Pharmacol. 2016 Nov 15;791:773-779. doi: 10.1016/j.ejphar.2016.09.038. PubMed PMID: 27693800.

2: Yunoki T, Zhu HL, Iwasa K, Tomoda T, Aishima M, Shibata A, Naito S, Teramoto N. Comparative studies of ZD0947, a novel ATP-sensitive K(+) channel opener, on guinea pig detrusor and aortic smooth muscles. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jan;376(5):309-19. PubMed PMID: 18071674.

3: Aishima M, Tomoda T, Yunoki T, Nakano T, Seki N, Yonemitsu Y, Sueishi K, Naito S, Ito Y, Teramoto N. Actions of ZD0947, a novel ATP-sensitive K+ channel opener, on membrane currents in human detrusor myocytes. Br J Pharmacol. 2006 Nov;149(5):542-50. PubMed PMID: 17016513; PubMed Central PMCID: PMC2014675.

4: Abdel-Karim AM, Bialecki RA, Elhilali MM. Effects of ZD6169 and ZD0947, 2 potassium adenosine triphosphate channel openers, on bladder function of spinalized rats. J Urol. 2002 Aug;168(2):837-42. PubMed PMID: 12131377.

5: Chapple CR, Patroneva A, Raines SR. Effect of an ATP-sensitive potassium channel opener in subjects with overactive bladder: a randomized, double-blind, placebo-controlled study (ZD0947IL/0004). Eur Urol. 2006 May;49(5):879-86. PubMed PMID: 16517051.


5.0mg / USD 285.0