BV600022

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530498

CAS#: 2086266-40-0

Description: BV600022 is an osteoadsorptive bisphosphonate-ciprofloxacin conjugate. In vitro antimicrobial susceptibility testing of BV600022 against common osteomyelitis pathogens revealed an effective bactericidal profile and sustained release of the parent antibiotic over time. Efficacy and safety were demonstrated in an animal model of periprosthetic osteomyelitis, where a single dose of 10 mg/kg (15.6 µmol/kg) BV600022 reduced the bacterial load by 99% and demonstrated nearly an order of magnitude greater activity than the parent antibiotic ciprofloxacin (30 mg/kg, 90.6 µmol/kg) given in multiple doses.

Chemical Structure

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BV600022
CAS# 2086266-40-0
Instruction

Theoretical Analysis

MedKoo Cat#: 530498
Name: BV600022
CAS#: 2086266-40-0
Chemical Formula: C26H28FN3O11P2
Exact Mass: 639.12
Molecular Weight: 639.466
Elemental Analysis: C, 48.84; H, 4.41; F, 2.97; N, 6.57; O, 27.52; P, 9.69

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: BV600022; BV-600022; BV 600022.

IUPAC/Chemical Name: 1-cyclopropyl-7-(4-((4-(2,2-diphosphonoethyl)phenoxy)carbonyl)piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

InChi Key: KWBYIXPNFABCJK-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H28FN3O11P2/c27-20-12-18-21(30(16-3-4-16)14-19(24(18)31)25(32)33)13-22(20)28-7-9-29(10-8-28)26(34)41-17-5-1-15(2-6-17)11-23(42(35,36)37)43(38,39)40/h1-2,5-6,12-14,16,23H,3-4,7-11H2,(H,32,33)(H2,35,36,37)(H2,38,39,40)

SMILES Code: O=C(N1CCN(C2=CC(N(C3CC3)C=C(C(O)=O)C4=O)=C4C=C2F)CC1)OC5=CC=C(CC(P(O)(O)=O)P(O)(O)=O)C=C5

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Osteomyelitis is a major problem worldwide, and is devastating due to the potential for limb-threatening sequelae and mortality. Osteomyelitis pathogens are bone-attached biofilms, making antibiotic delivery challenging. BV600022 incorporating a bisphosphonate and an antibiotic for bone-targeted delivery to treat osteomyelitis biofilm pathogens constitute a promising approach to providing high bone-antimicrobial potency while minimizing systemic exposure.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 639.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sedghizadeh PP, Sun S, Junka AF, Richard E, Sadrerafi K, Mahabady S,
Bakhshalian N, Tjokro N, Bartoszewicz M, Oleksy M, Szymczyk P, Lundy MW,
Neighbors JD, Russell RG, McKenna CE, Ebetino FH. Design, synthesis, and
antimicrobial evaluation of a novel bone-targeting bisphosphonate-ciprofloxacin
conjugate for the treatment of osteomyelitis biofilms. J Med Chem. 2017 Jan 25.
doi: 10.1021/acs.jmedchem.6b01615. [Epub ahead of print] PubMed PMID: 28121436.